Linked Life Data

18777192

Source:http://linkedlifedata.com/resource/pubmed/id/18777192

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2009-11-25
pubmed:abstractText
From 2002-2004, the Lung Screening Study (LSS) of the National Lung Screening Trial (NLST) enrolled 34,614 participants, aged 55-74 years, at increased risk for lung cancer due to heavy cigarette smoking. Participants, randomized to standard chest X-ray (CXR) or computed tomography (CT) arms at ten screening centers, received up to three imaging screens for lung cancer at annual intervals. Participant medical histories and radiologist-interpreted screening results were transmitted to the LSS coordinating center, while all images were retained at local screening centers. From 2005-2007, all CT exams were uniformly de-identified and delivered to a central repository, the CT Image Library (CTIL), on external hard drives (94%) or CD/DVD (5.9%), or over a secure Internet connection (0.1%). Of 48,723 CT screens performed, only 176 (0.3%) were unavailable (lost, corrupted, compressed) while 48,547 (99.7%) were delivered to the CTIL. Described here is the experience organizing, implementing, and adapting the clinical-trial workflow surrounding the image retrieval, de-identification, delivery, and archiving of available LSS-NLST CT exams for the CTIL, together with the quality assurance procedures associated with those collection tasks. This collection of CT exams, obtained in a specific, well-defined participant population under a common protocol at evenly spaced intervals, and its attending demographic and clinical information, are now available to lung-disease investigators and developers of computer-aided-diagnosis algorithms. The approach to large scale, multi-center trial CT image collection detailed here may serve as a useful model, while the experience reported should be valuable in the planning and execution of future equivalent endeavors.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1618-727X
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
22
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
667-80
pubmed:dateRevised
2011-7-26
pubmed:meshHeading
pubmed-meshheading:18777192-Aged, pubmed-meshheading:18777192-Data Collection, pubmed-meshheading:18777192-Early Detection of Cancer, pubmed-meshheading:18777192-Female, pubmed-meshheading:18777192-Humans, pubmed-meshheading:18777192-Lung Neoplasms, pubmed-meshheading:18777192-Male, pubmed-meshheading:18777192-Mass Screening, pubmed-meshheading:18777192-Medical Records Systems, Computerized, pubmed-meshheading:18777192-Middle Aged, pubmed-meshheading:18777192-Quality Control, pubmed-meshheading:18777192-Radiographic Image Interpretation, Computer-Assisted, pubmed-meshheading:18777192-Radiography, Thoracic, pubmed-meshheading:18777192-Radiology Information Systems, pubmed-meshheading:18777192-Risk Assessment, pubmed-meshheading:18777192-Tomography, X-Ray Computed, pubmed-meshheading:18777192-United States
pubmed:year
2009
pubmed:articleTitle
Collecting 48,000 CT exams for the lung screening study of the National Lung Screening Trial.
pubmed:affiliation
Mallinckrodt Institute of Radiology, Washington University, 510 South Kingshighway, Saint Louis, MO 63110, USA. clarkk@mir.wustl.edu
pubmed:publicationType
Journal Article, Randomized Controlled Trial, Multicenter Study