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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3 Pt 1
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pubmed:dateCreated |
1991-9-26
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pubmed:abstractText |
Myocardial high-energy phosphate metabolism in patients with dilated cardiomyopathy (DCM) of ischemic or idiopathic etiology was assessed at rest by one-dimensional phase-encoded 31P-nuclear magnetic resonance (NMR) spectroscopy studies performed in conjunction with 1H imaging in 20 patients with DCM and in 12 normal volunteers. The measured values of anterior myocardial phosphocreatine/beta-adenosine triphosphate (PCr/beta-ATP), corrected for partial saturation and contamination of the spectra by blood metabolites, averaged 1.80 +/- 0.06 (mean +/- SE) in normal volunteers and 1.46 +/- 0.07 in the patients overall, a highly significant (p less than 0.001) decrease. In patients with DCM accompanied by coronary artery disease (n = 9), the PCr/beta-ATP ratio averaged 1.53 +/- 0.07, while in those with DCM alone it was 1.41 +/- 0.12 (n = 11), a value that was not significantly different. There was no significant correlation (r = 0.34) between myocardial PCr/ATP ratio and left ventricular ejection fraction in patients. These studies demonstrate that myocardial PCr/ATP ratios are reduced at rest in human ischemic and idiopathic dilated cardiomyopathy.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0002-8703
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
122
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
795-801
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pubmed:dateRevised |
2006-2-27
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pubmed:meshHeading |
pubmed-meshheading:1877457-Adenosine Triphosphate,
pubmed-meshheading:1877457-Cardiomyopathy, Dilated,
pubmed-meshheading:1877457-Humans,
pubmed-meshheading:1877457-Magnetic Resonance Imaging,
pubmed-meshheading:1877457-Magnetic Resonance Spectroscopy,
pubmed-meshheading:1877457-Middle Aged,
pubmed-meshheading:1877457-Myocardial Contraction,
pubmed-meshheading:1877457-Myocardium,
pubmed-meshheading:1877457-Phosphocreatine,
pubmed-meshheading:1877457-Ventricular Function, Left
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pubmed:year |
1991
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pubmed:articleTitle |
Altered myocardial high-energy phosphate metabolites in patients with dilated cardiomyopathy.
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pubmed:affiliation |
GE Corporate Research and Development Center, Schenectady, NY 12301.
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pubmed:publicationType |
Journal Article
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