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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2008-9-5
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pubmed:abstractText |
Contexts and discrete cues associated with drug-taking are often responsible for relapse among addicts. Animal models have shown that interference with the reconsolidation of drug-cue memories can reduce seeking of drugs or drug-paired stimuli. One such model is conditioned place preference (CPP) in which an animal is trained to associate a particular environment with the rewarding effects of a drug. Previous work from this laboratory has shown that intra-nucleus accumbens core infusions of a MEK inhibitor can interfere with reconsolidation of these drug-cue memories. A question that remains is whether post-retrieval drug effects on subsequent memories represent an interference with reconsolidation processes or rather a facilitation of extinction. In this experiment, we explore the effect of post-retrieval injections of propranolol, a beta-adrenergic receptor antagonist, on reconsolidation and extinction of cocaine CPP. After acquisition of cocaine CPP, animals were given post-retrieval propranolol injections once or each day during a protocol of unreinforced preference tests, until the animals showed no preference for the previously cocaine-paired environment. Following a cocaine priming injection, the animals that received daily post-test propranolol injections did not reinstate their preference for the drug-paired side. In contrast, a single post-retrieval propranolol injection followed by multiple days of unreinforced preference tests failed to blunt subsequent cocaine reinstatement of the memory. These data suggest that daily post-retrieval systemic injections of propranolol decrease the conditioned preference by interfering with reconsolidation of the memory for the association between the drug-paired side and the reinforcing effects of the drug, rather than facilitating new extinction learning.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18772251-10753974,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18772251-10996406,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18772251-11477427,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18772251-12441048,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18772251-15073322,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18772251-15496662,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18772251-15501585,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18772251-15886718,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18772251-16157275,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18772251-16157281,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18772251-16492789,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18772251-16540579,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18772251-16600394,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18772251-16738229,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18772251-16769132,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18772251-16932155,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18772251-17471065,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18772251-17604134,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18772251-17912055,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18772251-18235109,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18772251-3136393,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18772251-6686696
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1549-5485
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
15
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
643-8
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pubmed:dateRevised |
2011-5-12
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pubmed:meshHeading |
pubmed-meshheading:18772251-Adrenergic beta-Antagonists,
pubmed-meshheading:18772251-Animals,
pubmed-meshheading:18772251-Behavior, Addictive,
pubmed-meshheading:18772251-Brain,
pubmed-meshheading:18772251-Cocaine,
pubmed-meshheading:18772251-Cocaine-Related Disorders,
pubmed-meshheading:18772251-Conditioning, Operant,
pubmed-meshheading:18772251-Cues,
pubmed-meshheading:18772251-Dopamine Uptake Inhibitors,
pubmed-meshheading:18772251-Extinction, Psychological,
pubmed-meshheading:18772251-Male,
pubmed-meshheading:18772251-Memory,
pubmed-meshheading:18772251-Rats,
pubmed-meshheading:18772251-Rats, Sprague-Dawley
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pubmed:year |
2008
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pubmed:articleTitle |
Post-retrieval beta-adrenergic receptor blockade: effects on extinction and reconsolidation of cocaine-cue memories.
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pubmed:affiliation |
Department of Neurobiology and Behavior, Center for the Neurobiology of Learning and Memory, University of California, Irvine, California 92697, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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