Linked Life Data

18771728

Source:http://linkedlifedata.com/resource/pubmed/id/18771728

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2009-5-19
pubmed:abstractText
The objective was to investigate the transdermal delivery kinetics of zolmitriptan from an iontophoretic patch system in Yorkshire swine in vivo. Preliminary in vitro experiments showed that cumulative drug transport during a 6-h current application (0.25 mA cm(-2)) was independent of patch load (263.7+/-92.7, 357.2+/-85.9, 374.9+/-74.3 and 335.9+/-27.7 microg cm(-2) for 7.5, 15, 45 and 90 mg patch loads, respectively; ANOVA, p<0.05); the steady-state flux was approximately 92 microg cm(-2)h(-1). The in vivo studies used multistep current profiles to demonstrate (i) rapid drug uptake and (ii) the effect of superposing a bolus input on basal drug levels. In both studies, zolmitriptan was detected in the blood after 2.5 min; drug levels were 7.11.7 and 10.4+/-3.5 ng ml(-1) at t=30 min in Studies 1 and 2, respectively. In Study 2, increasing current intensity from 0.2 to 1.4 mA (0.05-0.35 mA cm(-2)) at t=180 min caused zolmitriptan levels to rise from 9.38+/-0.93 ng ml(-1) at t=180 min to 13.57+/-1.85 ng ml(-1) at t=190 min; a approximately 50% increase in 10 min. Extrapolation of these results to humans suggests the feasibility of delivering therapeutic amounts of zolmitriptan at faster rates than those from existing dosage forms.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1873-3441
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
72
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
304-9
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Controlled non-invasive transdermal iontophoretic delivery of zolmitriptan hydrochloride in vitro and in vivo.
pubmed:affiliation
Vyteris, Inc, Fair Lawn, NJ 07410, USA.
pubmed:publicationType
Journal Article, In Vitro