Linked Life Data

18770854

Source:http://linkedlifedata.com/resource/pubmed/id/18770854

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2008-9-4
pubmed:abstractText
Dissipation of the mitochondrial membrane potential (DeltaPsi(m)) has been accepted as a hallmark of some apoptotic processes. Depending on the model studied, it can occur during the early stages of cell death or later on, after loss of DNA integrity. Discordant data in the literature could be the consequence of using improper probes such as rhodamine 123 (R123) or DiOC(6)(3), which are not always appropriate for the study of DeltaPsi(m). The lipophilic cation JC-1, a specific probe for measuring DeltaPsi(m), is currently the gold standard. Thanks to recently developed instruments and additional probes for cell surface and intracellular markers, it can be used in polychromatic flow cytometric assays to simultaneously detect DeltaPsi(m) along with other biological parameters.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1934-9300
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
Chapter 7
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
Unit7.32
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Polychromatic analysis of mitochondrial membrane potential using JC-1.
pubmed:affiliation
Department of Biomedical Sciences, General Pathology Section, University of Modena and Reggio Emilia, Modena, Italy.
pubmed:publicationType
Journal Article