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18770069
Source:
http://linkedlifedata.com/resource/pubmed/id/18770069
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rdf:type
pubmed:Citation
lifeskim:mentions
umls-concept:C0031957
,
umls-concept:C0243072
,
umls-concept:C0243077
pubmed:issue
1
pubmed:dateCreated
2009-1-26
pubmed:abstractText
Synthesis and enzymatic evaluation of new series of N(4)-substituted piperazine naphthamide derivatives as BACE-1 inhibitors for the treatment of Alzheimer's disease are reported.
pubmed:language
eng
pubmed:journal
http://linkedlifedata.com/resource/pubmed/journal/101150203
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Amides
,
http://linkedlifedata.com/resource/pubmed/chemical/Amyloid Precursor Protein Secretases
,
http://linkedlifedata.com/resource/pubmed/chemical/Amyloid beta-Peptides
,
http://linkedlifedata.com/resource/pubmed/chemical/Aspartic Acid Endopeptidases
,
http://linkedlifedata.com/resource/pubmed/chemical/BACE1 protein, human
,
http://linkedlifedata.com/resource/pubmed/chemical/Carboxylic Acids
,
http://linkedlifedata.com/resource/pubmed/chemical/Piperazines
,
http://linkedlifedata.com/resource/pubmed/chemical/Protease Inhibitors
,
http://linkedlifedata.com/resource/pubmed/chemical/naphthenic acid
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1475-6374
pubmed:author
pubmed-author:DessolinJJ
,
pubmed-author:GarinoCC
,
pubmed-author:KrausJ-LJL
,
pubmed-author:LarasYY
,
pubmed-author:MoretVV
,
pubmed-author:RollandAA
,
pubmed-author:WeckCC
pubmed:issnType
Electronic
pubmed:volume
24
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
181-7
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed-meshheading:18770069-Alzheimer Disease
,
pubmed-meshheading:18770069-Amides
,
pubmed-meshheading:18770069-Amyloid Precursor Protein Secretases
,
pubmed-meshheading:18770069-Amyloid beta-Peptides
,
pubmed-meshheading:18770069-Aspartic Acid Endopeptidases
,
pubmed-meshheading:18770069-Carboxylic Acids
,
pubmed-meshheading:18770069-Humans
,
pubmed-meshheading:18770069-Piperazines
,
pubmed-meshheading:18770069-Protease Inhibitors
pubmed:year
2009
pubmed:articleTitle
New N(4)-substituted piperazine naphthamide derivatives as BACE-1 inhibitors.
pubmed:affiliation
Laboratoire de Chimie Biomoleculaire, Faculte des Sciences Luminy, IBDML-UMR-6216-CNRS, Universite de la Mediterranee, Marseille Cedex, France.
pubmed:publicationType
Journal Article