Linked Life Data

18769922

Source:http://linkedlifedata.com/resource/pubmed/id/18769922

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2008-12-16
pubmed:abstractText
The aim of this study was to investigate the association of single nucleotide polymorphisms (SNPs) in tissue non-specific alkaline phosphatase (TNAP) with ankylosing spondylitis (AS) in the Chinese Han population. We carried out both case-control studies in two independent Chinese AS cohorts (Eastern Chinese, Southeastern Chinese) involving 353 AS patients and 514 unrelated healthy controls and family-based association study involving 57 pedigrees. Two TNAP intronic SNPs rs3767155 (G/A), and rs1780329 (G/T) and 1 exonic variant rs3738099 (A/G) were genotyped using direct DNA sequencing method. The results showed that there was no significant difference in allele, genotype or haplotype frequencies between the AS patients and the controls at the three SNPs in either case-control or family-based association study, which indicated that the TNAP gene was unlikely to play a major role in the susceptibility to AS in the Chinese Han population.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0172-8172
pubmed:author
pubmed:issnType
Print
pubmed:volume
29
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
305-10
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
No significant association between genetic polymorphisms in the TNAP gene and ankylosing spondylitis in the Chinese Han population.
pubmed:affiliation
Department of Medical Genetics, Second Military Medical University, 800 Xiangyin Road, 200433, Shanghai, People's Republic of China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't