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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2008-11-25
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pubmed:abstractText |
Extranodal nasal-type NK cell lymphoma (ENKL) is a high-grade malignancy and associated with EBV latent infection. An optimal therapy has not been discovery. Here, we investigated whether cell proliferation was inhibited by silencing Epstein-Barr virus nuclear antigen 1 (EBNA1) using RNA interference (RNAi) method in an EBV-positive ENKL cell line, HANK1 cells. We found that silencing EBNA1 expression by RNAi strategy inhibited cell growth and increased the expression of p27 protein and caused cell cycle arrest at G(1)-phase in HANK1 cells. In conclusions, low-level expression of p27 protein may partially attribute to latent EBV infection in ENKL. EBNA1 may be a good target for the treatment of EBV associated ENKL.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1555-8576
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
7
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1602-6
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pubmed:meshHeading |
pubmed-meshheading:18769118-Cell Cycle,
pubmed-meshheading:18769118-Cell Proliferation,
pubmed-meshheading:18769118-Cyclin-Dependent Kinase Inhibitor p27,
pubmed-meshheading:18769118-DNA Primers,
pubmed-meshheading:18769118-Disease Progression,
pubmed-meshheading:18769118-Epstein-Barr Virus Infections,
pubmed-meshheading:18769118-Epstein-Barr Virus Nuclear Antigens,
pubmed-meshheading:18769118-G1 Phase,
pubmed-meshheading:18769118-Gene Silencing,
pubmed-meshheading:18769118-Herpesvirus 4, Human,
pubmed-meshheading:18769118-Humans,
pubmed-meshheading:18769118-Killer Cells, Natural,
pubmed-meshheading:18769118-Lymphoma,
pubmed-meshheading:18769118-Lymphoma, T-Cell,
pubmed-meshheading:18769118-RNA Interference
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pubmed:year |
2008
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pubmed:articleTitle |
Suppression of EBNA1 expression inhibits growth of EBV-positive NK/T cell lymphoma cells.
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pubmed:affiliation |
Department of Pathology, The Third Affiliated Hospital of Sun Yat Sen University, Tian He District, Guangzhou, Guangdong, China.
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pubmed:publicationType |
Journal Article
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