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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
22
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pubmed:dateCreated |
2008-10-27
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pubmed:abstractText |
During H5N1 influenza virus infection, proinflammatory cytokines are markedly elevated in the lungs of infected hosts. The significance of this dysregulated cytokine response in H5N1-mediated pathogenesis remains to be determined. To investigate the influence of hypercytokinemia, or "cytokine storm," a transgenic mouse technology was used. The classical NF-kappaB pathway regulates the induction of most proinflammatory cytokines. Deletion of the p50 subunit leads to a markedly reduced expression of the NF-kappaB-regulated cytokines and chemokines. Here we show that H5N1 influenza virus infection of this transgenic mouse model resulted in a lack of hypercytokinemia but not in altered pathogenesis.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18768968-10602461,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18768968-11413336,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18768968-11932409,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18768968-12480361,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18768968-12773387,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18768968-14985470,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18768968-14987888,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18768968-15143063,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18768968-15145317,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18768968-15240757,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18768968-15748278,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18768968-16140756,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18768968-16192482,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18768968-16283933,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18768968-16469051,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18768968-16945126,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18768968-16964257,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18768968-17131933,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18768968-17182684,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18768968-17230189,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18768968-17324159,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18768968-17419881,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18768968-17640882,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18768968-17712756,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18768968-18411340,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18768968-18423196,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18768968-314763,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18768968-9341780,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18768968-9449698
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1098-5514
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
82
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
11461-6
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:18768968-Animals,
pubmed-meshheading:18768968-Body Weight,
pubmed-meshheading:18768968-Cytokines,
pubmed-meshheading:18768968-Influenza A Virus, H5N1 Subtype,
pubmed-meshheading:18768968-Mice,
pubmed-meshheading:18768968-Mice, Knockout,
pubmed-meshheading:18768968-NF-kappa B p50 Subunit,
pubmed-meshheading:18768968-Orthomyxoviridae Infections,
pubmed-meshheading:18768968-Severity of Illness Index,
pubmed-meshheading:18768968-Survival Analysis
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pubmed:year |
2008
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pubmed:articleTitle |
Role of hypercytokinemia in NF-kappaB p50-deficient mice after H5N1 influenza A virus infection.
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pubmed:affiliation |
Friedrich-Loeffler-Institut, Institute of Immunology, Federal Research Institute for Animal Health, Paul-Ehrlich Str. 28, D-72076 Tübingen, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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