Linked Life Data

18766960

Source:http://linkedlifedata.com/resource/pubmed/id/18766960

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2008-9-3
pubmed:abstractText
Chronic myeloid leukemia (CML) is a hematopoietic stem cell disease with distinct biological and clinical features. The Philadelphia (Ph) chromosome and BCR/ABL fusion gene is the major cytogenetic and molecular marker of CML chronic phase. However, the molecular mechanisms of disease progression are not well known. Recent studies have shown that a several of transcription factors such as AML1, C/EBPalpha, HOX and GATA family play important role in hematopoiesis. In addition, the aberrations of these transcription factors including mutations or translocations have also been found to contribute the disease progression. Hence, BCR/ABL and aberrant transcription factors may result in the phenotype of CML blast crisis together.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1029-2403
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
49
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1463-9
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
The role of aberrant transcription factor in the progression of chronic myeloid leukemia.
pubmed:affiliation
Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China. sujiangzhang@hotmail.com
pubmed:publicationType
Journal Article, Review