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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
14
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pubmed:dateCreated |
2008-9-3
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pubmed:abstractText |
Extracellular matrix is a crucial regulator of development, plasticity and regeneration in the nervous system. We have now found that N-syndecan, the receptor for the extracellular matrix component heparin-binding growth-associated molecule, is required for survival of primary sensory neurons. We demonstrate massive cell death of cultured dorsal root ganglion (DRG) neurons from mice deficient in the N-syndecan gene as compared with wild-type controls. Importantly, this cell death could not be prevented by nerve growth factor - the neurotrophin, which activates multiple antiapoptotic cascades in DRG neurons. The survival deficiency was observed during first postnatal week. In contrast, DRG neurons from young adult N-syndecan knockout mice exhibited normal survival. This study identifies a completely new syndecan-dependent type of signaling that regulates cell death in neurons.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1473-558X
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
17
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pubmed:volume |
19
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1397-400
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:18766019-Animals,
pubmed-meshheading:18766019-Carrier Proteins,
pubmed-meshheading:18766019-Cell Death,
pubmed-meshheading:18766019-Cell Survival,
pubmed-meshheading:18766019-Cells, Cultured,
pubmed-meshheading:18766019-Cytokines,
pubmed-meshheading:18766019-Ganglia, Spinal,
pubmed-meshheading:18766019-Glial Cell Line-Derived Neurotrophic Factor,
pubmed-meshheading:18766019-Growth Cones,
pubmed-meshheading:18766019-Immunohistochemistry,
pubmed-meshheading:18766019-Mice,
pubmed-meshheading:18766019-Mice, Inbred C57BL,
pubmed-meshheading:18766019-Mice, Knockout,
pubmed-meshheading:18766019-Nerve Growth Factor,
pubmed-meshheading:18766019-Neurons, Afferent,
pubmed-meshheading:18766019-Neurturin,
pubmed-meshheading:18766019-Receptor, trkA,
pubmed-meshheading:18766019-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:18766019-Signal Transduction,
pubmed-meshheading:18766019-Syndecans
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pubmed:year |
2008
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pubmed:articleTitle |
Sensory neurons from N-syndecan-deficient mice are defective in survival.
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pubmed:affiliation |
Institute of Biotechnology, PO Box 56, Viikki Biocenter, University of Helsinki, Helsinki FIN-00014, Finland. Mikhail.Paveliev@helsinki.fi
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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