|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
9
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|
pubmed:dateCreated |
2008-9-10
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|
pubmed:abstractText |
A structure-activity relationship (SAR) study of bastadin 6 (1), a brominated tyrosine-derived metabolite from Indonesian marine sponge having a potent anti-angiogenic activity, was executed. The syntheses and their biological evaluation of the oxime-modified analogues and bromine-modified analogues revealed that both the oxime moieties and bromine atoms in bastadin 6 (1) play an important role to show the potent and selective anti-proliferative activity against human umbilical vein endothelial cells (HUVECs).
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Sep
|
|
pubmed:issn |
0365-6233
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
341
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
568-77
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|
pubmed:dateRevised |
2008-11-21
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|
pubmed:meshHeading |
|
|
pubmed:year |
2008
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|
pubmed:articleTitle |
Structure-activity relationships study of bastadin 6, an anti-angiogenic brominated-tyrosine derived metabolite from marine sponge.
|
|
pubmed:affiliation |
Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka, Japan.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
