Linked Life Data

18763024

Source:http://linkedlifedata.com/resource/pubmed/id/18763024

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2009-1-16
pubmed:abstractText
Previous studies have shown that bioactive glasses possessed antibacterial effect on common bacteria due to the high aqueous pH value caused by the bioactive glass dissolution. In the present study, the efficiency of the antibacterial effect of 45S5 Bioglass (45S5 BAG) against S. aureus, S. epidermidis and E. coli and its mechanism were investigated. The results showed that 45S5 BAG exhibited a strong antibacterial effect against the bacteria, and the sensitivity of gram-negative and gram-positive bacteria to Bioglass was different. Furthermore, a dose-dependent bacterial adhesion on 45S5 BAG particles and the formation of needle-like Bioglass debris were observed, which resulted in the damage of cell walls and inactivation of bacteria. The results suggested that both the high pH and bioglass debris on the surface of bacteria may be the possible mechanisms of the antibacterial effect of 45S5 BAG particulates.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0957-4530
pubmed:author
pubmed:issnType
Print
pubmed:volume
20
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
281-6
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Study on antibacterial effect of 45S5 Bioglass.
pubmed:affiliation
Biomaterials and Tissue Engineering Research Center, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't