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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2008-12-18
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pubmed:abstractText |
Induction of CYP3A by St. John's wort (SJW) products with high hyperforin content is well described. Since CYP3A induction is mediated by hyperforin in a concentration-dependent manner, and SJW preparations differ significantly in hyperforin content, the aim of the study was to evaluate the effect of an SJW powder with low hyperforin content on CYP3A function.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1432-1041
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pubmed:author |
pubmed-author:DrewelowBerndB,
pubmed-author:FrankBrunoB,
pubmed-author:KlammtSebastianS,
pubmed-author:KundtGuentherG,
pubmed-author:LehnfeldRomanusR,
pubmed-author:Majcher-PeszynskaJolantaJ,
pubmed-author:MuellerSilke CSC,
pubmed-author:MundkowskiRalf GRG,
pubmed-author:SieversHartwigH,
pubmed-author:ThurowKerstinK,
pubmed-author:UehlekeBernhardB
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pubmed:issnType |
Electronic
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pubmed:volume |
65
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
81-7
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pubmed:meshHeading |
pubmed-meshheading:18762932-Administration, Oral,
pubmed-meshheading:18762932-Adult,
pubmed-meshheading:18762932-Bicyclo Compounds,
pubmed-meshheading:18762932-Cross-Over Studies,
pubmed-meshheading:18762932-Cytochrome P-450 CYP3A,
pubmed-meshheading:18762932-Enzyme Induction,
pubmed-meshheading:18762932-Herb-Drug Interactions,
pubmed-meshheading:18762932-Humans,
pubmed-meshheading:18762932-Hypericum,
pubmed-meshheading:18762932-Male,
pubmed-meshheading:18762932-Midazolam,
pubmed-meshheading:18762932-Phloroglucinol,
pubmed-meshheading:18762932-Plant Preparations,
pubmed-meshheading:18762932-Powders,
pubmed-meshheading:18762932-Substrate Specificity,
pubmed-meshheading:18762932-Terpenes,
pubmed-meshheading:18762932-Young Adult
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pubmed:year |
2009
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pubmed:articleTitle |
No clinically relevant CYP3A induction after St. John's wort with low hyperforin content in healthy volunteers.
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pubmed:affiliation |
Center of Pharmacology and Toxicology, Institute of Clinical Pharmacology, University of Rostock, Schillingallee 70, 18057 Rostock, Germany. silke.mueller@med.uni-rostock.de
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, Non-U.S. Gov't
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