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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2008-11-13
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pubmed:abstractText |
Angiostatin, a circulating angiogenic inhibitor, is an internal fragment of plasminogen and consists of several isoforms, K1-3 included. We previously showed that K1-3 was the most potent angiostatin to induce E-selectin mRNA expression. The purpose of this study was to identify the mechanism responsible for K1-3-induced E-selectin expression and investigate the role of E-selectin in the anti-angiogenic action of K1-3.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1538-7836
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1953-61
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:18761727-Angiostatins,
pubmed-meshheading:18761727-Binding Sites,
pubmed-meshheading:18761727-Caveolin 1,
pubmed-meshheading:18761727-Cell Line,
pubmed-meshheading:18761727-Cell Line, Tumor,
pubmed-meshheading:18761727-E-Selectin,
pubmed-meshheading:18761727-Humans,
pubmed-meshheading:18761727-JNK Mitogen-Activated Protein Kinases,
pubmed-meshheading:18761727-Kinetics,
pubmed-meshheading:18761727-Membrane Microdomains,
pubmed-meshheading:18761727-Promoter Regions, Genetic,
pubmed-meshheading:18761727-Protein Binding,
pubmed-meshheading:18761727-Protein Isoforms,
pubmed-meshheading:18761727-Proto-Oncogene Protein c-ets-1,
pubmed-meshheading:18761727-RNA, Messenger,
pubmed-meshheading:18761727-Transcription Factor AP-1,
pubmed-meshheading:18761727-Transcriptional Activation
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pubmed:year |
2008
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pubmed:articleTitle |
Angiostatin K1-3 induces E-selectin via AP1 and Ets1: a mediator for anti-angiogenic action of K1-3.
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pubmed:affiliation |
Institute of Basic Medical Sciences, College of Mdicine, National Cheng Kung University, Tainan, Taiwa, ROC.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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