Linked Life Data

18761708

Source:http://linkedlifedata.com/resource/pubmed/id/18761708

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pubmed-article:18761708pubmed:abstractTextActivated microglia participate in neuroinflammation which contributes to neuronal damage in neurodegenerative diseases. Inhibition of microglial activation may have potential anti-inflammatory effects. Our laboratory has previously reported that triptolide, a natural biologically active compound extracted from Tripterygium wilfordii, could protect dopaminergic neurons from inflammation-mediated damage. However, the mechanism by which triptolide inhibits inflammation remains unknown. We reported here that inhibition of prostaglandin E(2) (PGE(2)) production could be a potential mechanism of triptolide to suppress inflammation. Triptolide suppressed c-jun NH2-terminal kinase (JNK) phosphorylation, cyclooxygenase 2 (COX-2) expression and PGE(2) production in microglial cultures treated with lipopolysaccharide (LPS). Triptolide also greatly inhibited the transcriptional activity, but not the DNA-binding activity of nuclear factor-kappaB (NF-kappaB) in microglia following LPS stimulation. These results indicate that triptolide might suppress NF-kappaB activity to down-regulate COX-2 expression. The LPS-stimulated transcriptional activity of NF-kappaB was suppressed by inhibition of p38MAPK, but not by that of JNK and extracellular signal-regulated kinase. Furthermore, the LPS-induced PGE(2) production was reduced by inhibiting these kinases. Taken together, these results suggest that triptolide may suppress neuroinflammation via a mechanism that involves inactivation of two parallel signaling pathways: p38-NF-kappaB-COX-2-PGE(2) and JNK-PGE(2).lld:pubmed
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pubmed-article:18761708pubmed:authorpubmed-author:XueBingBlld:pubmed
pubmed-article:18761708pubmed:authorpubmed-author:WangXiaominXlld:pubmed
pubmed-article:18761708pubmed:authorpubmed-author:GongYuntaoYlld:pubmed
pubmed-article:18761708pubmed:authorpubmed-author:JingLimingLlld:pubmed
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pubmed-article:18761708pubmed:dateRevised2009-11-19lld:pubmed
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pubmed-article:18761708pubmed:articleTitleTriptolide inhibits COX-2 expression and PGE2 release by suppressing the activity of NF-kappaB and JNK in LPS-treated microglia.lld:pubmed
pubmed-article:18761708pubmed:affiliationDepartment of Neurobiology, School of Basic Medical Sciences, Peking University Health Science Center, Ministry of Education, Key Laboratory for Neuroscience, Beijing, China.lld:pubmed
pubmed-article:18761708pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:18761708pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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