Linked Life Data

18761002

Source:http://linkedlifedata.com/resource/pubmed/id/18761002

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2008-11-17
pubmed:abstractText
Neural progenitor cells (NPCs) have drawn attention because they offer possible treatment for neurodegenerative disorders in the form of regenerative therapy or transplantation. NPCs adapt and change in response to the cues in the pathological environment. We assessed the effect of pre-exposure to non-cytotoxic levels of oxidative stress, a common pathogenic factor in a number of neurological disorders, on the cell viability and neurosphere morphology of NPCs derived from the periventricular zone of mice brain. Neural progenitor cell viability and neurosphere morphology (neurosphere number, size and chain migration) were assessed in response to cytotoxic levels of oxidative stress in the presence or absence of preconditioning with non-cytotoxic doses of hydrogen peroxide (H(2)O(2)). Preconditioning with non-cytotoxic levels of H(2)O(2) provided significant protection against subsequent exposure to lethal doses of H(2)O(2). Preconditioning also modulated alteration in the neurosphere morphology in response to oxidative stress. Oxidative stress increased chain migration and neurosphere size while decreasing neurosphere numbers, specially in the cultures that were preconditioned with higher doses of H(2)O(2). Non-cytotoxic exposure to oxidative stress can evoke endogenous cytoprotection in NPCs. Redox signaling plays a role in other cellular functions of NPCs, namely the chain migration of NPCs from neurospheres, perhaps as a result of its effect on cell differentiation.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1872-6240
pubmed:author
pubmed:issnType
Electronic
pubmed:day
3
pubmed:volume
1243
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
19-26
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Effect of oxidative preconditioning on neural progenitor cells.
pubmed:affiliation
Department of Ophthalmology and Hamilton Eye Institute, University of Tennessee Health Science Center, 930 Madison Ave, Memphis, TN 38163, USA. rksharma@utmem.edu
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural