Linked Life Data

18760881

Source:http://linkedlifedata.com/resource/pubmed/id/18760881

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2009-1-1
pubmed:abstractText
In the process of promoting wound healing, epidermal growth factor (EGF) activates protein kinase C, protein tyrosine kinase and ERK MAPK (mitogen-activated protein kinase). The activation of these mediators in signal pathways can regulate the operation of K(+) channels. In addition, the K(+) channel is involved with cell migration and proliferation, both of which are requisite for wound healing. Recent studies, although not conducted on skin wounds, have found that the K(+) channel is associated with wound healing and that wound healing can be promoted by regulating the K(+) channels. Therefore, the authors hypothesize that healing of skin wounds could be promoted by regulating K(+) channel distribution in skin keratinocytes or fibroblasts. We plan to conduct a study of the promotion of skin wound healing using K(+) channel regulators.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0306-9877
pubmed:author
pubmed:issnType
Print
pubmed:volume
71
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
927-9
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Regulation of K(+) channels may enhance wound healing in the skin.
pubmed:affiliation
Department of Physiology, Institute of Health Sciences, College of Medicine, Gyeongsang National University, Jinju, Republic of Korea.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't