|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
3
|
|
pubmed:dateCreated |
2009-1-27
|
|
pubmed:abstractText |
We investigated the association between GSTM1 or GSTT1 polymorphisms and clinical outcomes in 133 younger patients with AML of intermediate-risk cytogenetics. Clinical outcomes were not significantly different among the GSTM1 polymorphism genotypes, whereas cumulative incidence of relapse (CIR) was significantly lower and event-free survival (EFS) was significantly higher in patients with the GSTT1-present genotype compared with those with the GSTT1-null genotype (CIR at 5 year, 28.9% vs. 44.6%, P=0.018; EFS at 5 year, 51.4% vs. 34.1%, P=0.029). Our results suggest that GSTT1 gene polymorphism has significant clinical implications in younger patients with AML of intermediate-risk cytogenetics.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Mar
|
|
pubmed:issn |
1873-5835
|
|
pubmed:author |
pubmed-author:ChiHyun SookHS,
pubmed-author:HurEun-HyeEH,
pubmed-author:JangSeongsooS,
pubmed-author:KangMun JungMJ,
pubmed-author:KangSol-IpSI,
pubmed-author:KangYoung-AhYA,
pubmed-author:KimDae-YoungDY,
pubmed-author:KimSe HyungSH,
pubmed-author:KimYang SooYS,
pubmed-author:LeeHo SupHS,
pubmed-author:LeeJe-HwanJH,
pubmed-author:LeeJung-HeeJH,
pubmed-author:LeeKyoo-HyungKH,
pubmed-author:LeeMichael JinpyoMJ,
pubmed-author:LeeYoung-ShinYS,
pubmed-author:ParkChan JeoungCJ,
pubmed-author:RyuSeong-GilSG,
pubmed-author:SeoEul-JuEJ,
pubmed-author:SeolMieeM,
pubmed-author:YunSung-CheolSC
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
33
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
426-33
|
|
pubmed:meshHeading |
pubmed-meshheading:18760837-Adolescent,
pubmed-meshheading:18760837-Adult,
pubmed-meshheading:18760837-Age Factors,
pubmed-meshheading:18760837-Cytogenetic Analysis,
pubmed-meshheading:18760837-Disease-Free Survival,
pubmed-meshheading:18760837-Female,
pubmed-meshheading:18760837-Glutathione Transferase,
pubmed-meshheading:18760837-Humans,
pubmed-meshheading:18760837-Leukemia, Myeloid, Acute,
pubmed-meshheading:18760837-Male,
pubmed-meshheading:18760837-Middle Aged,
pubmed-meshheading:18760837-Polymorphism, Genetic,
pubmed-meshheading:18760837-Prognosis,
pubmed-meshheading:18760837-Recurrence,
pubmed-meshheading:18760837-Risk Factors,
pubmed-meshheading:18760837-Treatment Outcome,
pubmed-meshheading:18760837-Young Adult
|
|
pubmed:year |
2009
|
|
pubmed:articleTitle |
Clinical significance of GSTM1 and GSTT1 polymorphisms in younger patients with acute myeloid leukemia of intermediate-risk cytogenetics.
|
|
pubmed:affiliation |
Department of Internal Medicine, Kosin University Gospel Hospital, Busan, Republic of Korea.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
