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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2008-9-1
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pubmed:abstractText |
The route of transmission of most naturally acquired transmissible spongiform encephalopathy (TSE) infections remains speculative. To investigate urine as a potential source of TSE exposure, we used a sensitive method for detection and quantitation of TSE infectivity. Pooled urine collected from 22 hamsters showing clinical signs of 263K scrapie contained 3.8 +/- 0.9 infectious doses/mL of infectivity. Titration of homogenates of kidneys and urinary bladders from the same animals gave concentrations 20,000-fold greater. Histologic and immunohistochemical examination of these same tissues showed no indications of inflammatory or other pathologic changes except for occasional deposits of disease-associated prion protein in kidneys. Although the source of TSE infectivity in urine remains unresolved, these results establish that TSE infectivity is excreted in urine and may thereby play a role in the horizontal transmission of natural TSEs. The results also indicate potential risk for TSE transmission from human urine-derived hormones and other medicines.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18760007-11423531,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18760007-12351519,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18760007-12721194,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18760007-14778593,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18760007-15302197,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18760007-15661974,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18760007-15855301,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18760007-15911815,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18760007-16102323,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18760007-16224026,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18760007-16617377,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18760007-16672586,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18760007-16950892,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18760007-16954698,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18760007-16958834,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18760007-16971175,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18760007-17023660,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18760007-17098992,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18760007-17189034,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18760007-17502917,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18760007-17535913,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18760007-17848990,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18760007-2957510,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18760007-4986938,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18760007-6015529,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18760007-6407995,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18760007-7494055,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18760007-8179297,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18760007-9738619
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1080-6059
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1406-12
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
2008
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pubmed:articleTitle |
Excretion of transmissible spongiform encephalopathy infectivity in urine.
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pubmed:affiliation |
Veterans Affairs Medical Center, Baltimore, Maryland 21201, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, N.I.H., Extramural
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