| pubmed-article:1875946 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1875946 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:1875946 | lifeskim:mentions | umls-concept:C0017258 | lld:lifeskim |
| pubmed-article:1875946 | lifeskim:mentions | umls-concept:C0034987 | lld:lifeskim |
| pubmed-article:1875946 | lifeskim:mentions | umls-concept:C0002270 | lld:lifeskim |
| pubmed-article:1875946 | lifeskim:mentions | umls-concept:C0205164 | lld:lifeskim |
| pubmed-article:1875946 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
| pubmed-article:1875946 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:1875946 | pubmed:dateCreated | 1991-9-20 | lld:pubmed |
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| pubmed-article:1875946 | pubmed:abstractText | The major positive regulatory activity of the human alpha-globin gene complex has been localized to an element associated with a strong erythroid-specific DNase I hypersensitive site (HS -40) located 40 kb upstream of the zeta 2-globin mRNA cap site. Footprint and gel shift analyses of the element have demonstrated the presence of four binding sites for the nuclear factor GATA-1 and two sites corresponding to the AP-1 consensus binding sequence. This region resembles one of the major elements of the beta-globin locus control region in its constitution and characteristics; this together with evidence from expression studies suggests that HS -40 is a primary element controlling alpha-globin gene expression. | lld:pubmed |
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| pubmed-article:1875946 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1875946 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1875946 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1875946 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1875946 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:1875946 | pubmed:issn | 0270-7306 | lld:pubmed |
| pubmed-article:1875946 | pubmed:author | pubmed-author:WoodW GWG | lld:pubmed |
| pubmed-article:1875946 | pubmed:author | pubmed-author:HiggsD RDR | lld:pubmed |
| pubmed-article:1875946 | pubmed:author | pubmed-author:SharpeJ AJA | lld:pubmed |
| pubmed-article:1875946 | pubmed:author | pubmed-author:AyyubHH | lld:pubmed |
| pubmed-article:1875946 | pubmed:author | pubmed-author:GourdonGG | lld:pubmed |
| pubmed-article:1875946 | pubmed:author | pubmed-author:JarmanA PAP | lld:pubmed |
| pubmed-article:1875946 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1875946 | pubmed:volume | 11 | lld:pubmed |
| pubmed-article:1875946 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1875946 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1875946 | pubmed:pagination | 4679-89 | lld:pubmed |
| pubmed-article:1875946 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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