|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
9
|
|
pubmed:dateCreated |
1991-9-20
|
|
pubmed:databankReference |
|
|
pubmed:abstractText |
The major positive regulatory activity of the human alpha-globin gene complex has been localized to an element associated with a strong erythroid-specific DNase I hypersensitive site (HS -40) located 40 kb upstream of the zeta 2-globin mRNA cap site. Footprint and gel shift analyses of the element have demonstrated the presence of four binding sites for the nuclear factor GATA-1 and two sites corresponding to the AP-1 consensus binding sequence. This region resembles one of the major elements of the beta-globin locus control region in its constitution and characteristics; this together with evidence from expression studies suggests that HS -40 is a primary element controlling alpha-globin gene expression.
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1875946-1701260,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1875946-1975428,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1875946-2116990,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1875946-2159150,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1875946-2202110,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1875946-2217202,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1875946-2235483,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1875946-2253879,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1875946-2295312,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1875946-2320113,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1875946-2355926,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1875946-2357964,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1875946-2357965,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1875946-2364173,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1875946-2403638,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1875946-2461328,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1875946-2612906,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1875946-2620826,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1875946-2704733,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1875946-2721958,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1875946-2725505,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1875946-2725678,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1875946-2748594,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1875946-2771941,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1875946-2772649,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1875946-2780563,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1875946-2822260,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1875946-2831456,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1875946-2843293,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1875946-2911469,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1875946-2911489,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1875946-2911581,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1875946-2922063,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1875946-2924354,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1875946-3034432,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1875946-3034433,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1875946-3052270,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1875946-3139301,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1875946-3141060,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1875946-3166139,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1875946-3243278,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1875946-3319186,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1875946-3413070,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1875946-3480506,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1875946-3690667,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1875946-3719696,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1875946-3858676,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1875946-3879975,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1875946-6205764,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1875946-6246368,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1875946-6828386,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1875946-7460013,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1875946-948749
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Sep
|
|
pubmed:issn |
0270-7306
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
11
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
4679-89
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
|
