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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2008-10-7
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pubmed:abstractText |
Elevated hepatic lipase (HL, also known as LIPC) expression is a key factor in the development of the atherogenic lipid profile in type 2 diabetes and insulin resistance. Recently, genetic screens revealed a possible association of type 2 diabetes and familial combined hyperlipidaemia with the USF1 gene. Therefore, we investigated the role of upstream stimulatory factors (USFs) in the regulation of HL.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA Primers,
http://linkedlifedata.com/resource/pubmed/chemical/Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/Lipase,
http://linkedlifedata.com/resource/pubmed/chemical/USF1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/USF2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Upstream Stimulatory Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Usf1 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Usf2 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/hepatic lipase, human
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0012-186X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
51
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2078-87
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:18758746-Animals,
pubmed-meshheading:18758746-Cell Line,
pubmed-meshheading:18758746-Cell Line, Tumor,
pubmed-meshheading:18758746-DNA Primers,
pubmed-meshheading:18758746-Female,
pubmed-meshheading:18758746-Gene Expression Regulation, Enzymologic,
pubmed-meshheading:18758746-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:18758746-Glucose,
pubmed-meshheading:18758746-Hepatoblastoma,
pubmed-meshheading:18758746-Humans,
pubmed-meshheading:18758746-Lipase,
pubmed-meshheading:18758746-Liver Neoplasms,
pubmed-meshheading:18758746-Oligonucleotide Array Sequence Analysis,
pubmed-meshheading:18758746-Promoter Regions, Genetic,
pubmed-meshheading:18758746-Rats,
pubmed-meshheading:18758746-Rats, Wistar,
pubmed-meshheading:18758746-Transcription, Genetic,
pubmed-meshheading:18758746-Up-Regulation,
pubmed-meshheading:18758746-Upstream Stimulatory Factors
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pubmed:year |
2008
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pubmed:articleTitle |
Glucose increases hepatic lipase expression in HepG2 liver cells through upregulation of upstream stimulatory factors 1 and 2.
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pubmed:affiliation |
Department of Biochemistry, Cardiovascular Research School COEUR, Erasmus MC, Rotterdam, The Netherlands.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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