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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2008-9-1
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pubmed:abstractText |
Signal-transducing adaptor protein-2 (STAP-2) is a recently identified adaptor protein as a c-Fms/M-CSF receptor-interacting protein and constitutively expressed in macrophages. In our previous study, we examined the role of STAP-2 in the c-Fms/M-CSF receptor signaling using a murine macrophage tumor cells line, Raw264.7. Overexpression of STAP-2 in Raw264.7 cells markedly suppressed M-CSF-induced activation of extracellular signal regulated kinase and Akt. In addition, Raw264.7 overexpressing STAP-2 affected cell migration in wound-healing process. These results suggest that STAP-2 deficiency influences endogenous c-Fms/M-CSF receptor signaling. Here we show that loss of STAP-2 expression in knockout mouse macrophages results in marked enhancement of the c-Fms/M-CSF receptor signaling and wound-healing process. We therefore propose that STAP-2 acts as an endogenous regulator in normal macrophages functions.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0918-6158
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
31
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1790-3
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:18758078-Adaptor Proteins, Signal Transducing,
pubmed-meshheading:18758078-Animals,
pubmed-meshheading:18758078-Blotting, Western,
pubmed-meshheading:18758078-Cell Movement,
pubmed-meshheading:18758078-Cell Proliferation,
pubmed-meshheading:18758078-Extracellular Signal-Regulated MAP Kinases,
pubmed-meshheading:18758078-Flow Cytometry,
pubmed-meshheading:18758078-Humans,
pubmed-meshheading:18758078-Macrophages,
pubmed-meshheading:18758078-Mice,
pubmed-meshheading:18758078-Mice, Knockout,
pubmed-meshheading:18758078-Oncogene Protein v-akt,
pubmed-meshheading:18758078-Receptor, Macrophage Colony-Stimulating Factor,
pubmed-meshheading:18758078-Recombinant Proteins,
pubmed-meshheading:18758078-Signal Transduction,
pubmed-meshheading:18758078-Wound Healing
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pubmed:year |
2008
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pubmed:articleTitle |
Enhanced c-Fms/M-CSF receptor signaling and wound-healing process in bone marrow-derived macrophages of signal-transducing adaptor protein-2 (STAP-2) deficient mice.
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pubmed:affiliation |
Department of Immunology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita-ku Kita 12 Nishi 6, Sapporo, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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