18757511

Source:http://linkedlifedata.com/resource/pubmed/id/18757511

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0086222, umls-concept:C0205094, umls-concept:C0205095, umls-concept:C0205321, umls-concept:C0332237, umls-concept:C0441635, umls-concept:C1522168, umls-concept:C1522223, umls-concept:C1705733, umls-concept:C1883036, umls-concept:C2745293
pubmed:issue	2
pubmed:dateCreated	2009-1-27
pubmed:abstractText	This study was designed to characterize ocular penetration pathways of ESBA105, a topically administered single-chain antibody (scFv) against tumor necrosis factor (TNF)-alpha, to the anterior and posterior segment of the eye.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/7703701
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal, http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin Fragments, http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin Variable Region, http://linkedlifedata.com/resource/pubmed/chemical/Ophthalmic Solutions, http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha, http://linkedlifedata.com/resource/pubmed/chemical/immunoglobulin Fv
pubmed:status	MEDLINE
pubmed:month	Feb
pubmed:issn	1552-5783
pubmed:author	pubmed-author:FeigeUlrichU, pubmed-author:LichtlenPeterP, pubmed-author:OttigerMichaelM, pubmed-author:ThielMichael AMA, pubmed-author:UrechDavid MDM
pubmed:issnType	Electronic
pubmed:volume	50
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	779-86
pubmed:meshHeading	pubmed-meshheading:18757511-Absorption, pubmed-meshheading:18757511-Administration, Topical, pubmed-meshheading:18757511-Animals, pubmed-meshheading:18757511-Anterior Eye Segment, pubmed-meshheading:18757511-Antibodies, Monoclonal, pubmed-meshheading:18757511-Aqueous Humor, pubmed-meshheading:18757511-Biological Availability, pubmed-meshheading:18757511-Enzyme-Linked Immunosorbent Assay, pubmed-meshheading:18757511-Half-Life, pubmed-meshheading:18757511-Immunoglobulin Fragments, pubmed-meshheading:18757511-Immunoglobulin Variable Region, pubmed-meshheading:18757511-Male, pubmed-meshheading:18757511-Ophthalmic Solutions, pubmed-meshheading:18757511-Rabbits, pubmed-meshheading:18757511-Retina, pubmed-meshheading:18757511-Tissue Distribution, pubmed-meshheading:18757511-Tumor Necrosis Factor-alpha, pubmed-meshheading:18757511-Vitreous Body
pubmed:year	2009
pubmed:articleTitle	Efficient intraocular penetration of topical anti-TNF-alpha single-chain antibody (ESBA105) to anterior and posterior segment without penetration enhancer.
pubmed:affiliation	ESBATech AG, Schlieren, Switzerland.
pubmed:publicationType	Journal Article