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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2008-8-29
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pubmed:abstractText |
Bacille Calmette-Guérin (BCG) induces potent Th1 responses with the help of interleukin (IL)-10 and IL-12 released from dendritic cells (DCs), and suppresses Th2- associated allergic reactions. However, there are still some controversies on therapeutic effects of BCG in asthmatics. This study investigated whether BCG administration to DCs suppresses IL-5 production from T cells in atopic asthmatics. DCs derived from peripheral blood of subjects were cultured with or without BCG and Dermatophagoides farinae extract. Some DCs were co-cultured with T cells in the presence of BCG or the above culture supernatants. In the atopic asthmatics, BCG significantly increased IL-10 and IL-12 production from DCs. In the presence of D. farinae extract, BCG further increased IL-10 production. BCG-induced IL-10 production was significantly higher in the atopics (n=14) than in the non-atopics (n=9). Both BCG and the BCG-treated DCs culture supernatant significantly increased IFN-gamma production from T cells. Both BCG and the supernatant from DCs+BCG+D. farinae co-cultures significantly decreased IL-5 production (all p<0.05), but the supernatant from DCs+BCG co-cultures did not. In conclusion, administration of BCG together with D. farinae extract effectively decreased IL-5 production from T cells, probably through the action of IL-10 and IL-12 released from DCs in D. farinae-sensitive asthmatics.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18756049-10340945,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18756049-10657938,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18756049-10669857,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18756049-10779751,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18756049-11240956,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18756049-11371410,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18756049-11457534,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18756049-11722624,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18756049-11799371,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18756049-11859146,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18756049-12042815,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18756049-12086366,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18756049-14987299,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18756049-15191022,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18756049-15482516,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18756049-15483336,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18756049-16400898,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18756049-16701150,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18756049-17176788,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18756049-17517055,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18756049-8006603,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18756049-8499055,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18756049-8642294,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18756049-9338786,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18756049-9463406,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18756049-9640239,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18756049-9819307
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1011-8934
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
23
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
628-34
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:18756049-Adult,
pubmed-meshheading:18756049-Asthma,
pubmed-meshheading:18756049-BCG Vaccine,
pubmed-meshheading:18756049-Dendritic Cells,
pubmed-meshheading:18756049-Female,
pubmed-meshheading:18756049-Humans,
pubmed-meshheading:18756049-Interferon-gamma,
pubmed-meshheading:18756049-Interleukin-10,
pubmed-meshheading:18756049-Interleukin-12,
pubmed-meshheading:18756049-Interleukin-5,
pubmed-meshheading:18756049-Lymphocyte Activation,
pubmed-meshheading:18756049-Male,
pubmed-meshheading:18756049-T-Lymphocytes
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pubmed:year |
2008
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pubmed:articleTitle |
BCG-induced dendritic cell responses and suppression of interleukin-5 production from T cells in atopic asthmatics.
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pubmed:affiliation |
Department of Allergy, Chonnam National University Medical School, Dong-gu, Gwangju, Korea. ischoi@chonnam.chonnam.ac.kr
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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