|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
5
|
|
pubmed:dateCreated |
2008-11-5
|
|
pubmed:abstractText |
The R577X polymorphism in the alpha-actinin-3 encoding gene (ACTN3) has been associated with elite athletic performance, and recently with differences in isometric and dynamic muscle strength and power in the general population. In this study we sought to determine the association of ACTN3 R577X genotype with muscle strength and mass phenotypes in men and women across the adult age span. Eight hundred forty-eight (n = 848) adult volunteers (454 men and 394 women) aged 22-90 yr were genotyped for ACTN3 R577X. Knee extensor (KE) shortening and lengthening peak torque values were determined using isokinetic dynamometry and fat-free mass (FFM) by dual-energy X-ray absorptiometry. Women deficient in alpha-actinin-3 (X/X; n = 53) displayed lower KE shortening peak torque (30 degrees /s: 89.5 +/- 3.5 vs. 99.3 +/- 1.4 N.m, P = 0.011; 180 degrees /s: 60.3 +/- 2.6 vs. 67.0 +/- 1.0 N.m, P = 0.019) and KE lengthening peak torque (30 degrees /s: 122.8 +/- 5.7 vs. 137.0 +/- 2.2 N.m, P = 0.022; 180 degrees /s: 121.8 +/- 5.8 vs. 138.5 +/- 2.2 N.m, P = 0.008) compared with R/X + R/R women (n = 341). Women X/X homozygotes also displayed lower levels of both total body FFM (38.9 +/- 0.5 vs. 40.1 +/- 0.2 kg, P = 0.040) and lower limb FFM (11.9 +/- 0.2 vs. 12.5 +/- 0.1 kg, P = 0.044) compared with R/X + R/R women. No genotype-related differences were observed in men. In conclusion, our results indicate that the absence of alpha-actinin-3 protein (i.e., ACTN3 X/X genotype) influences KE peak torque and FFM in women but not men.
|
|
pubmed:grant |
http://linkedlifedata.com/resource/pubmed/grant/AG-021500,
http://linkedlifedata.com/resource/pubmed/grant/AG-022791,
http://linkedlifedata.com/resource/pubmed/grant/K01 AG022791-02,
http://linkedlifedata.com/resource/pubmed/grant/K01 AG022791-03,
http://linkedlifedata.com/resource/pubmed/grant/K01 AG022791-04,
http://linkedlifedata.com/resource/pubmed/grant/K01 AG022791-05,
http://linkedlifedata.com/resource/pubmed/grant/L30 AG024705-02,
http://linkedlifedata.com/resource/pubmed/grant/L30 AG024705-03,
http://linkedlifedata.com/resource/pubmed/grant/R01 AG021500-01A1,
http://linkedlifedata.com/resource/pubmed/grant/R01 AG021500-02,
http://linkedlifedata.com/resource/pubmed/grant/R01 AG021500-03
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18756004-10192379,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18756004-11440986,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18756004-11716195,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18756004-12879365,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18756004-15221860,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18756004-15292341,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18756004-15377647,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18756004-15718405,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18756004-15886711,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18756004-16371478,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18756004-17033684,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18756004-17347381,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18756004-17828264,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18756004-17848603,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18756004-17879893,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18756004-18043716,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18756004-18178581,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18756004-18470530,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18756004-18637739,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18756004-18650267,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18756004-2671039,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18756004-8887951,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18756004-8964743,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18756004-9094325,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18756004-9216968,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18756004-9375323,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18756004-9887130
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Nov
|
|
pubmed:issn |
8750-7587
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
105
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1486-91
|
|
pubmed:dateRevised |
2011-1-26
|
|
pubmed:meshHeading |
pubmed-meshheading:18756004-Absorptiometry, Photon,
pubmed-meshheading:18756004-Actinin,
pubmed-meshheading:18756004-Adult,
pubmed-meshheading:18756004-Age Factors,
pubmed-meshheading:18756004-Aged,
pubmed-meshheading:18756004-Aged, 80 and over,
pubmed-meshheading:18756004-Female,
pubmed-meshheading:18756004-Humans,
pubmed-meshheading:18756004-Knee,
pubmed-meshheading:18756004-Longitudinal Studies,
pubmed-meshheading:18756004-Male,
pubmed-meshheading:18756004-Middle Aged,
pubmed-meshheading:18756004-Muscle, Skeletal,
pubmed-meshheading:18756004-Muscle Contraction,
pubmed-meshheading:18756004-Muscle Strength,
pubmed-meshheading:18756004-Muscle Strength Dynamometer,
pubmed-meshheading:18756004-Phenotype,
pubmed-meshheading:18756004-Polymorphism, Genetic,
pubmed-meshheading:18756004-Sex Factors,
pubmed-meshheading:18756004-Torque,
pubmed-meshheading:18756004-Young Adult
|
|
pubmed:year |
2008
|
|
pubmed:articleTitle |
ACTN3 genotype is associated with muscle phenotypes in women across the adult age span.
|
|
pubmed:affiliation |
Department of Kinesiology, School of Public Health, University of Maryland, College Park, MD 20742-2611, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
|
