Source:http://linkedlifedata.com/resource/pubmed/id/18755802
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2008-12-30
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| pubmed:abstractText |
The estrogen receptor-alpha knockout (ERalphaKO, ERalpha-/-) mice were generated via the Cre-loxP system by mating floxed ERalpha mice with beta-actin (ACTB)-Cre mice. The impact of ERalpha gene deletion in the male reproductive system was investigated. The ACTB-Cre/ERalpha(-/-) male mice are infertile and have lost 90% of epididymal sperm when compared with wild-type mice. Serum testosterone levels in ACTB-Cre/ERalpha(-/-) male mice are 2-fold elevated. The ACTB-Cre/ERalpha(-/-) testes consist of atrophic and degenerating seminiferous tubules with less cellularity in the disorganized seminiferous epithelia. Furthermore, the ventral and dorsal-lateral prostates of ACTB-Cre/ERalpha(-/-) mice display reduced branching morphogenesis. Loss of ERalpha could also be responsible for the decreased fibroblast proliferation and changes in the stromal content. In addition, we found bone morphogenetic protein, a mesenchymal inhibitor of prostatic branching morphogenesis, is significantly up-regulated in the ACTB-Cre/ERalpha(-/-) prostates. Collectively, these results suggest that ERalpha is required for male fertility, acts through a paracrine mechanism to regulate prostatic branching morphogenesis, and is involved in the proliferation and differentiation of prostatic stromal compartment.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Desmin,
http://linkedlifedata.com/resource/pubmed/chemical/Estrogen Receptor alpha,
http://linkedlifedata.com/resource/pubmed/chemical/Fibroblast Growth Factor 2,
http://linkedlifedata.com/resource/pubmed/chemical/Testosterone,
http://linkedlifedata.com/resource/pubmed/chemical/Vimentin
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| pubmed:status |
MEDLINE
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| pubmed:month |
Jan
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| pubmed:issn |
0013-7227
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
150
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
251-9
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| pubmed:meshHeading |
pubmed-meshheading:18755802-Animals,
pubmed-meshheading:18755802-Atrophy,
pubmed-meshheading:18755802-Desmin,
pubmed-meshheading:18755802-Estrogen Receptor alpha,
pubmed-meshheading:18755802-Fibroblast Growth Factor 2,
pubmed-meshheading:18755802-Humans,
pubmed-meshheading:18755802-Infertility, Male,
pubmed-meshheading:18755802-Male,
pubmed-meshheading:18755802-Mice,
pubmed-meshheading:18755802-Mice, Knockout,
pubmed-meshheading:18755802-Morphogenesis,
pubmed-meshheading:18755802-Prostate,
pubmed-meshheading:18755802-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:18755802-Seminiferous Tubules,
pubmed-meshheading:18755802-Sperm Count,
pubmed-meshheading:18755802-Testis,
pubmed-meshheading:18755802-Testosterone,
pubmed-meshheading:18755802-Vimentin
|
| pubmed:year |
2009
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| pubmed:articleTitle |
Defects of prostate development and reproductive system in the estrogen receptor-alpha null male mice.
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| pubmed:affiliation |
Department of Urology, University of Rochester Medical Center, 601 Elmwood Avenue, Box 656, Rochester, New York 14642, USA.
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| pubmed:publicationType |
Journal Article
|