Linked Life Data

18755648

Source:http://linkedlifedata.com/resource/pubmed/id/18755648

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2008-8-29
pubmed:abstractText
In spite of recent advances in cancer therapy, some tumors still remain incurable and novel therapeutic approaches need to be developed. Apoptosis is a cell death inducing mechanism and is actually one of the most obvious targets for cancer treatment. It becomes clear that this regulation is more complex than previously expected, and multiple signalling pathways for cell death have to be considered. Agents with the property of inducing tumor cell death, such as TNF/TNFR superfamily members, also called "death receptors", represent an attractive therapeutic approach. Our team identified another member of this family, HVEM and its ligand LIGHT, as promising therapeutic targets. HVEM was known as a costimulatory molecule, but this role is getting more complex with the identification of new ligands and the highlights of new functions. So, HVEM could combine a pro-apoptotic effect with the immune system activation. This review will first focus on mechanisms and new insights in therapeutic application of TNF receptors. Then we will present new functions for LIGHT and HVEM and how these functions may provide new opportunities for antitumoral therapy and more effective treatments.
pubmed:language
fre
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1769-6917
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
95
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
691-700
pubmed:dateRevised
2009-11-11
pubmed:meshHeading
pubmed:articleTitle
[Targeting TNF receptors in cancer therapy: toward a new role for LIGHT and HVEM].
pubmed:affiliation
Centre de recherche en cancérologie de Marseille, université de Méditerranée, IFR 137, institut de cancérologie et d'immunologie de Marseille, Inserm UMR599, 27, boulevard Leï-Roure, 13009 Marseille, France.
pubmed:publicationType
Journal Article, English Abstract, Review