|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
8
|
|
pubmed:dateCreated |
1991-9-25
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|
pubmed:abstractText |
The synthesis of a series of novel polyamine analogues is reported. The DNA binding of these compounds and a variety of other polyamines were compared with their IC50 values against HeLa cell. There seemed to be no apparent correlation between the DNA binding and toxicity against HeLa cells.
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|
pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Aug
|
|
pubmed:issn |
0022-2623
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
34
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
2414-20
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:1875339-Alkylation,
pubmed-meshheading:1875339-Antineoplastic Agents,
pubmed-meshheading:1875339-Base Composition,
pubmed-meshheading:1875339-Cell Division,
pubmed-meshheading:1875339-DNA,
pubmed-meshheading:1875339-Ethidium,
pubmed-meshheading:1875339-HeLa Cells,
pubmed-meshheading:1875339-Molecular Structure,
pubmed-meshheading:1875339-Polyamines,
pubmed-meshheading:1875339-Spermine,
pubmed-meshheading:1875339-Structure-Activity Relationship
|
|
pubmed:year |
1991
|
|
pubmed:articleTitle |
Synthesis and DNA-binding properties of polyamine analogues.
|
|
pubmed:affiliation |
Marion Merrell Dow Research Institute, Cincinnati, Ohio 45215.
|
|
pubmed:publicationType |
Journal Article,
Comparative Study
|
