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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2008-10-6
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pubmed:databankReference |
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pubmed:abstractText |
One hundred four bacterial strains mediating urinary tract infections in separate individuals from a Uruguayan community were isolated. Forty-six strains conferred a multidrug resistance phenotype. All 104 strains were examined for the presence of class 1, 2, and 3 integrons. Class 1 integrons were found in 21 isolates across four distinct bacterial genera. A large class 1 integron in a Klebsiella pneumoniae strain was fully sequenced and was 29,093 bp in length. This integron probably arose by homologous recombination since it was embedded in a hybrid Tn21-like transposon backbone which comprised a Tn5036-like tnp transposition module at the IRi integron end and a Tn21 mer module at the IRt integron end. The parent integron/transposon that contributed the Tn5036 module was not related to Tn1696 since the integron insertion points in the transposon backbones were 16 bases apart. Examination of the other 20 class 1 integron-containing strains revealed further evidence of genetic exchange. This included a strain that possessed a Tn5036 module at the IRt end but not at the IRi end and another that possessed a tnp module beyond IRi that was a hybrid of Tn21 and Tn5051 and that is presumed to have arisen by site-specific recombination. This study highlights the ability of different genetic elements to act cooperatively to spread and rearrange antibiotic resistance in a community.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18753343-10477306,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/18753343-8755869
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1098-660X
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
46
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3417-25
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:18753343-Humans,
pubmed-meshheading:18753343-Adolescent,
pubmed-meshheading:18753343-Infant,
pubmed-meshheading:18753343-Urinary Tract Infections,
pubmed-meshheading:18753343-Aged,
pubmed-meshheading:18753343-Aged, 80 and over,
pubmed-meshheading:18753343-Child,
pubmed-meshheading:18753343-Infant, Newborn,
pubmed-meshheading:18753343-Child, Preschool,
pubmed-meshheading:18753343-Enterobacteriaceae,
pubmed-meshheading:18753343-Female,
pubmed-meshheading:18753343-Male,
pubmed-meshheading:18753343-Adult,
pubmed-meshheading:18753343-Enterobacteriaceae Infections,
pubmed-meshheading:18753343-Middle Aged,
pubmed-meshheading:18753343-DNA, Bacterial
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