18752948

Source:http://linkedlifedata.com/resource/pubmed/id/18752948

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0003695, umls-concept:C0026452, umls-concept:C0299477, umls-concept:C0441472, umls-concept:C0441889, umls-concept:C0851285
pubmed:issue	22
pubmed:dateCreated	2008-11-10
pubmed:abstractText	The structure-activity relationships of organophosphorus (OP) and organosulfur compounds were examined in vitro and in vivo as inhibitors of mouse brain monoacylglycerol lipase (MAGL) hydrolysis of 2-arachidonoylglycerol (2-AG) and agonist binding at the CB1 receptor. Several compounds showed exceptional potency toward MAGL activity with IC(50) values of 0.1-10 nM in vitro and high inhibition at 10mg/kg intraperitoneally in mice. We find for the first time that MAGL activity is a major in vivo determinant of 2-AG and arachidonic acid levels not only in brain but also in spleen, lung, and liver. Apparent direct OP inhibition of CB1 agonist binding may be due instead to metabolic stabilization of 2-AG in brain membranes as the actual inhibitor.
pubmed:grant	http://linkedlifedata.com/resource/pubmed/grant/DA003672, http://linkedlifedata.com/resource/pubmed/grant/ES008762, http://linkedlifedata.com/resource/pubmed/grant/P01 DA009789-12A1, http://linkedlifedata.com/resource/pubmed/grant/R01 DA003672-09, http://linkedlifedata.com/resource/pubmed/grant/R01 DA003672-24A1, http://linkedlifedata.com/resource/pubmed/grant/R01 ES008762-02
pubmed:commentsCorrections	http://linkedlifedata.com/resource/pubmed/commentcorrection/18752948-10945879, http://linkedlifedata.com/resource/pubmed/commentcorrection/18752948-11470906, http://linkedlifedata.com/resource/pubmed/commentcorrection/18752948-12518029, http://linkedlifedata.com/resource/pubmed/commentcorrection/18752948-12944586, http://linkedlifedata.com/resource/pubmed/commentcorrection/18752948-14595399, http://linkedlifedata.com/resource/pubmed/commentcorrection/18752948-16310817, http://linkedlifedata.com/resource/pubmed/commentcorrection/18752948-16449251, http://linkedlifedata.com/resource/pubmed/commentcorrection/18752948-17257165, http://linkedlifedata.com/resource/pubmed/commentcorrection/18752948-17353660, http://linkedlifedata.com/resource/pubmed/commentcorrection/18752948-17979719, http://linkedlifedata.com/resource/pubmed/commentcorrection/18752948-18096503, http://linkedlifedata.com/resource/pubmed/commentcorrection/18752948-18292184, http://linkedlifedata.com/resource/pubmed/commentcorrection/18752948-18420277, http://linkedlifedata.com/resource/pubmed/commentcorrection/18752948-18429637, http://linkedlifedata.com/resource/pubmed/commentcorrection/18752948-18438404, http://linkedlifedata.com/resource/pubmed/commentcorrection/18752948-7575630, http://linkedlifedata.com/resource/pubmed/commentcorrection/18752948-7858978, http://linkedlifedata.com/resource/pubmed/commentcorrection/18752948-9037253
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/9107377
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/2-arachidonylglycerol, http://linkedlifedata.com/resource/pubmed/chemical/Arachidonic Acid, http://linkedlifedata.com/resource/pubmed/chemical/Arachidonic Acids, http://linkedlifedata.com/resource/pubmed/chemical/Glycerides, http://linkedlifedata.com/resource/pubmed/chemical/Monoacylglycerol Lipases, http://linkedlifedata.com/resource/pubmed/chemical/Organophosphorus Compounds, http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Cannabinoid, CB1, http://linkedlifedata.com/resource/pubmed/chemical/Sulfur Compounds
pubmed:status	MEDLINE
pubmed:month	Nov
pubmed:issn	1464-3405
pubmed:author	pubmed-author:AboodMary EME, pubmed-author:BurstonJames JJJ, pubmed-author:CasidaJohn EJE, pubmed-author:FisherKarl JKJ, pubmed-author:HudakCarolyn S SCS, pubmed-author:IssaRoger SRS, pubmed-author:LichtmanAron HAH, pubmed-author:NomuraDaniel KDK, pubmed-author:WardAnna MAM, pubmed-author:WileyJenny LJL
pubmed:issnType	Electronic
pubmed:day	15
pubmed:volume	18
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	5875-8
pubmed:dateRevised	2010-12-28
pubmed:meshHeading	pubmed-meshheading:18752948-Animals, pubmed-meshheading:18752948-Arachidonic Acid, pubmed-meshheading:18752948-Arachidonic Acids, pubmed-meshheading:18752948-Brain, pubmed-meshheading:18752948-Cell Membrane, pubmed-meshheading:18752948-Glycerides, pubmed-meshheading:18752948-Inhibitory Concentration 50, pubmed-meshheading:18752948-Mice, pubmed-meshheading:18752948-Molecular Structure, pubmed-meshheading:18752948-Monoacylglycerol Lipases, pubmed-meshheading:18752948-Organophosphorus Compounds, pubmed-meshheading:18752948-Receptor, Cannabinoid, CB1, pubmed-meshheading:18752948-Structure-Activity Relationship, pubmed-meshheading:18752948-Sulfur Compounds
pubmed:year	2008
pubmed:articleTitle	Monoacylglycerol lipase regulates 2-arachidonoylglycerol action and arachidonic acid levels.
pubmed:affiliation	Environmental Chemistry and Toxicology Laboratory, Department of Environmental Science, Policy and Management, 115 Wellman Hall, University of California, Berkeley, CA 94720-3112, USA.
pubmed:publicationType	Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural