Linked Life Data

1874218

Source:http://linkedlifedata.com/resource/pubmed/id/1874218

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1991-9-26
pubmed:abstractText
While the association of inhalational anaesthetics and verapamil has been shown to cause myocardial dysfunction, the interactions between fentanyl, verapamil and nitrous oxide on regional function in normal hearts have not been investigated. Seven mongrel dogs were instrumented to measure aortic and left-ventricular pressure, aortic blood flow and apical and basal regional left-ventricular function (sonomicrometry). Haemodynamic values were recorded during anaesthesia with 1% halothane, fentanyl 100 micrograms kg-1 (followed by 1.5 micrograms kg-1 min-1) and then after the addition of verapamil 250 micrograms kg-1 over 30 min (followed by 60 micrograms kg-1 min-1). At each stage 67% nitrous oxide was added and recordings obtained before and during its administration. The addition of verapamil during fentanyl anaesthesia caused a moderate depression of global haemodynamics. Only little dysfunction of the apical region (9.5 +/- 2.4% post-systolic shortening) was noted. The addition of nitrous oxide caused a small amount of additional depression without significant regional dysfunction.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0265-0215
pubmed:author
pubmed:issnType
Print
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
203-12
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Verapamil and nitrous oxide exert only minor effects on the normal myocardium in the presence of fentanyl.
pubmed:affiliation
McGill Department of Anaesthesia, McGill University, Montreal, Canada.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't