18728872

Source:http://linkedlifedata.com/resource/pubmed/id/18728872

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0108171, umls-concept:C0597486, umls-concept:C1512693, umls-concept:C1721062
pubmed:issue	34
pubmed:dateCreated	2008-8-27
pubmed:abstractText	We present an X-ray diffraction (XRD) and multi frequency electron spin resonance (ESR) study of the structure and dynamics of an inclusion complex of p-hexanoyl calix[4]arene (C6OH) with 4-methoxy-2,2,6,6-tetramethylpiperidine-N-oxyl (MT). The single crystal XRD experiments reveal that MT along with ethanol (solvent) molecules are entrapped in a capsular type crystalline lattice of the host C6OH material. ESR measurements were performed at 9.2 GHz/0.33 T (X-band) and at 360 GHz/14 T. In order to avoid ESR line broadening resulting from electron dipole-dipole interaction between nitroxides occupying neighbouring capsules in the crystal lattice, the capsules containing nitroxides were separated from each other by capsules containing diamagnetic dibenzylketone (DBK). Due to the extremely high g-tensor resolution of ESR at 360 GHz, we were able to distinguish, by shifts of their gxx component, between encapsulated nitroxide molecules forming a hydrogen bond between their O-(N) group and the OH group of an ethanol molecule occupying the same capsule and nitroxides missing this interaction. Temperature dependent ESR measurements revealed an orientational anisotropy in the motion of MT encapsulated in C6OH. Solid lipid nanoparticles (SLN) prepared from C6OH and loaded with the nitroxide retained the microcrystalline capsular structure of the pertinent inclusion complex. We found that encapsulated MT in SLNs becomes inaccessible to reducing agents such as sodium ascorbate.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/100888160
pubmed:status	PubMed-not-MEDLINE
pubmed:month	Sep
pubmed:issn	1463-9076
pubmed:author	pubmed-author:AnanchenkoGennady SGS, pubmed-author:BagryanskayaElena GEG, pubmed-author:ColemanAnthony WAW, pubmed-author:MöbiusKlausK, pubmed-author:PolovyanenkoDmitriy NDN, pubmed-author:RipmeesterJohn AJA, pubmed-author:SchneggAlexanderA, pubmed-author:UdachinKonstantin AKA
pubmed:issnType	Print
pubmed:day	14
pubmed:volume	10
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	5299-307
pubmed:year	2008
pubmed:articleTitle	Inclusion of 4-methoxy-2,2,6,6-tetramethylpiperidine-N-oxyl in a calixarene nanocapsule in the solid state.
pubmed:affiliation	International Tomography Center SB RAS, Novosibirsk, Russia.
pubmed:publicationType	Journal Article, Research Support, Non-U.S. Gov't