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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
1991-9-17
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pubmed:abstractText |
Two cis-diamminedichloroplatinum (II) (cisplatin)-inducible proteins [b 130 (approximately 130 kDa) and b95 (approximately 95 kDa]) in HeLa cells that recognize both the cisplatin-modified and u.v.-modified DNA were identified in this study. These damage-recognition proteins were overexpressed in cisplatin-resistant HeLa cells. The results suggest that the damage-recognition proteins are regulated in the cells in response to DNA damage, and they may be important for DNA repair and probably the emergence of cisplatin resistance.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1872817-1898714,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1872817-2005898,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1872817-2325644,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1872817-2333286,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1872817-2383564,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1872817-2919165,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1872817-2995982,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1872817-3045443,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1872817-3175673,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1872817-3309570,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1872817-3320059,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1872817-3886121,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1872817-4011711,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1872817-4075400,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1872817-6268142,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1872817-6287227,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1872817-6370067,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1872817-6606682,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1872817-6828386,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1872817-942051
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0264-6021
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
277 ( Pt 3)
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
875-8
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:1872817-Blotting, Southern,
pubmed-meshheading:1872817-Blotting, Western,
pubmed-meshheading:1872817-Cisplatin,
pubmed-meshheading:1872817-DNA,
pubmed-meshheading:1872817-DNA Damage,
pubmed-meshheading:1872817-DNA Repair,
pubmed-meshheading:1872817-DNA-Binding Proteins,
pubmed-meshheading:1872817-Drug Resistance,
pubmed-meshheading:1872817-Female,
pubmed-meshheading:1872817-HeLa Cells,
pubmed-meshheading:1872817-Humans,
pubmed-meshheading:1872817-Molecular Weight,
pubmed-meshheading:1872817-Ultraviolet Rays
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pubmed:year |
1991
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pubmed:articleTitle |
Identification of inducible damage-recognition proteins that are overexpressed in HeLa cells resistant to cis-diamminedichloroplatinum (II).
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pubmed:affiliation |
Department of Biochemistry, Chang Gung Medical College, Taoyuan, Taiwan, Republic of China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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