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rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0017337,
umls-concept:C0025914,
umls-concept:C0026809,
umls-concept:C0185117,
umls-concept:C0443199,
umls-concept:C0851827,
umls-concept:C1420283,
umls-concept:C1514562,
umls-concept:C1519249,
umls-concept:C1701901,
umls-concept:C1705241,
umls-concept:C1705242,
umls-concept:C2911684
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pubmed:dateCreated |
1991-9-17
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pubmed:abstractText |
The mouse U1b SnRNA gene is expressed in only a limited range of cell types, whereas the U1a SnRNA gene is expressed in all cells. These two genes differ in the sequence of the octamer motif, which plays a critical role in SnRNA gene regulation. We show that the U1b octamer binds the octamer-binding protein Oct-1 with higher affinity than does the U1a octamer in both U1b-expressing and -non-expressing cell lines and tissues. Moreover, the U1b octamer can direct a higher level of gene expression than the U1a octamer when linked to a heterologous promoter and introduced into a non-U1b-expressing cell line. Hence the tissue-specific expression of the U1b gene is not determined by the failure of its octamer motif to bind Oct-1 or the weak affinity of this binding.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1872807-1105573,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1872807-2126955,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1872807-2409453,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1872807-2412294,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1872807-26810,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1872807-2854059,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1872807-2950324,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1872807-3000882,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1872807-3027665,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1872807-3037497,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1872807-3119226,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1872807-3371356,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1872807-3462701,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1872807-3677172,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1872807-3921262,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1872807-5263016,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1872807-6198328,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1872807-6275366,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1872807-6425835,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1872807-6828386,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1872807-942051
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0264-6021
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
277 ( Pt 3)
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
719-22
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:1872807-Animals,
pubmed-meshheading:1872807-Base Sequence,
pubmed-meshheading:1872807-DNA-Binding Proteins,
pubmed-meshheading:1872807-Gene Expression,
pubmed-meshheading:1872807-Host Cell Factor C1,
pubmed-meshheading:1872807-Mice,
pubmed-meshheading:1872807-Molecular Sequence Data,
pubmed-meshheading:1872807-Octamer Transcription Factor-1,
pubmed-meshheading:1872807-RNA, Small Nuclear,
pubmed-meshheading:1872807-Regulatory Sequences, Nucleic Acid,
pubmed-meshheading:1872807-Transcription Factors
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pubmed:year |
1991
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pubmed:articleTitle |
Differential expression of the mouse U1a and U1b SnRNA genes is not dependent on sequence differences in the octamer motif.
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pubmed:affiliation |
Department of Biochemistry, University College and Middlesex School of Medicine, London, U.K.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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