Linked Life Data

18727915

Source:http://linkedlifedata.com/resource/pubmed/id/18727915

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2008-10-22
pubmed:abstractText
NS5ATP9 was previously identified as p15 PAF [proliferating cell nuclear antigen (PCNA)-associated factor] to bind with PCNA. We earlier identified the promoter region of NS5ATP9 and found NS5ATP9 is a NS5A up-regulation gene. However little is known about how it is regulated. To investigate the gene regulation of NS5ATP9, we screened NS5ATP9 promoter binding proteins using phage display and verified by electrophoretic mobility shift assay (EMSA). We found that the nuclear protein rhNF-kappaB (p50) could bind to the NS5ATP9 promoter and the binding region contained within a 156 bp (nucleotides -5 to -161bp) immediately upstream of the transcription initiation site. Our results suggest that NF-kappaB could participate in the regulation of NS5ATP9 gene expression in carcinogenesis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1096-0384
pubmed:author
pubmed:issnType
Electronic
pubmed:day
1
pubmed:volume
479
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
15-9
pubmed:dateRevised
2010-6-4
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
NS5ATP9 gene regulated by NF-kappaB signal pathway.
pubmed:affiliation
The First Hospital of Xi'an Jiaotong University, Xi'an, PR China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't