Linked Life Data

18727104

Source:http://linkedlifedata.com/resource/pubmed/id/18727104

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2008-9-1
pubmed:abstractText
The simultaneous binding of multiple ligands on one entity to multiple receptors on another can result in an affinity that is significantly greater than that for the binding of a single ligand to a single receptor. This concept of "polyvalency" can be used to design molecules that are potent inhibitors of toxins and pathogens. We describe the design of potent polyvalent inhibitors that neutralize anthrax toxin in vivo as well as our attempts to elucidate the relationship between inhibitor structure and activity. We also highlight promising future avenues for research in polyvalent drug design.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1097-0290
pubmed:author
pubmed:copyrightInfo
(c) 2008 Wiley Periodicals, Inc.
pubmed:issnType
Electronic
pubmed:day
15
pubmed:volume
101
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
429-34
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Polyvalency: a promising strategy for drug design.
pubmed:affiliation
The Howard P. Isermann Department of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, 110, 8th Street, Ricketts Building, Troy, New York 12180, USA.
pubmed:publicationType
Journal Article, Review