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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
13-14
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pubmed:dateCreated |
2008-9-22
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pubmed:abstractText |
The aim was to determine whether increased CK8 and BCRP expression cooperatively contribute to multidrug resistance (MDR) in MCF-7/MX cells. Accumulating evidence suggests that the development and maintenance of cancer MDR involves complex multimodal mechanisms that interact concomitantly and complementarily. In this report, we observed elevated expression of cytokeratin 8 (CK8) in MCF-7/MX, a mitoxantrone (MX)-selected human breast tumor cell line with the MDR phenotype known as overexpression of breast cancer resistant protein (BCRP).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/ABCG2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/ATP-Binding Cassette Transporters,
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Keratin-8,
http://linkedlifedata.com/resource/pubmed/chemical/Mitoxantrone,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Small Interfering,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Untranslated
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0024-3205
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
26
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pubmed:volume |
83
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
496-501
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pubmed:meshHeading |
pubmed-meshheading:18725232-ATP-Binding Cassette Transporters,
pubmed-meshheading:18725232-Animals,
pubmed-meshheading:18725232-Antineoplastic Agents,
pubmed-meshheading:18725232-Breast Neoplasms,
pubmed-meshheading:18725232-Cell Line, Tumor,
pubmed-meshheading:18725232-Cell Survival,
pubmed-meshheading:18725232-Drug Resistance, Multiple,
pubmed-meshheading:18725232-Drug Resistance, Neoplasm,
pubmed-meshheading:18725232-Gene Silencing,
pubmed-meshheading:18725232-Humans,
pubmed-meshheading:18725232-Keratin-8,
pubmed-meshheading:18725232-Mice,
pubmed-meshheading:18725232-Mitoxantrone,
pubmed-meshheading:18725232-NIH 3T3 Cells,
pubmed-meshheading:18725232-Neoplasm Proteins,
pubmed-meshheading:18725232-Phenotype,
pubmed-meshheading:18725232-RNA, Small Interfering,
pubmed-meshheading:18725232-RNA, Untranslated,
pubmed-meshheading:18725232-RNA Interference,
pubmed-meshheading:18725232-Transfection
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pubmed:year |
2008
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pubmed:articleTitle |
Co-expression of cytokeratin 8 and breast cancer resistant protein indicates a multifactorial drug-resistant phenotype in human breast cancer cell line.
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pubmed:affiliation |
State Key Laboratory of Experimental Hematology, Institute of Hematology & Hospital of Blood Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, PR China. byliufang@hotmail.com
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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