Source:http://linkedlifedata.com/resource/pubmed/id/18725063
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
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| pubmed:dateCreated |
2008-8-26
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| pubmed:abstractText |
Preliminary studies suggest that alpha[(11)C]methyl-l-tryptophan positron emission tomography can detect the epileptic focus within malformations of cortical development. We determined the sensitivity and specificity of alpha-[(11)C]methyl-l-tryptophan positron emission tomography in identifying epileptic focus in children with intractable, neocortical epilepsy with and without malformations of cortical development. Seventy-three epileptic children were classified into lesional and nonlesional groups, and compared regarding focal increased alpha-[(11)C]methyl-l-tryptophan uptake. The sensitivity and specificity of focal increased alpha-[(11)C]methyl-l-tryptophan uptake, using intracranial electroencephalogram localization of seizure onset as the standard, were compared between lesional and nonlesional groups. The specificity of alpha-[(11)C]methyl-l-tryptophan positron emission tomography for detecting seizure onset lobe was equally high in lesional (97%) and nonlesional groups (100%), whereas sensitivity was higher in the lesional than the nonlesional group (47% versus 29%; P = 0.047). The incidence of alpha-[(11)C]methyl-l-tryptophan uptake abnormality was higher in the lesional than the nonlesional group (P < 0.01). Alpha-[(11)C]methyl-l-tryptophan positron emission tomography localized and visualized epileptogenic regions in 25% of patients with nonlocalizing magnetic resonance imaging. Although overall sensitivity of alpha-[(11)C]methyl-l-tryptophan positron emission tomography in identifying neocortical epileptic focus is modest, specificity is extremely high. When an alpha-[(11)C]methyl-l-tryptophan focus is detected, it likely represents the epileptogenic region to be resected.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Sep
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| pubmed:issn |
0887-8994
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
39
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
181-8
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| pubmed:meshHeading |
pubmed-meshheading:18725063-Adolescent,
pubmed-meshheading:18725063-Brain,
pubmed-meshheading:18725063-Carbon Radioisotopes,
pubmed-meshheading:18725063-Cerebral Cortex,
pubmed-meshheading:18725063-Child,
pubmed-meshheading:18725063-Child, Preschool,
pubmed-meshheading:18725063-Electroencephalography,
pubmed-meshheading:18725063-Epilepsies, Partial,
pubmed-meshheading:18725063-Epilepsy,
pubmed-meshheading:18725063-Female,
pubmed-meshheading:18725063-Fluorodeoxyglucose F18,
pubmed-meshheading:18725063-Humans,
pubmed-meshheading:18725063-Injections, Intravenous,
pubmed-meshheading:18725063-Magnetic Resonance Imaging,
pubmed-meshheading:18725063-Male,
pubmed-meshheading:18725063-Malformations of Cortical Development,
pubmed-meshheading:18725063-Positron-Emission Tomography,
pubmed-meshheading:18725063-Reproducibility of Results,
pubmed-meshheading:18725063-Tryptophan
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| pubmed:year |
2008
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| pubmed:articleTitle |
Alpha-methyl-l-tryptophan positron emission tomography in epilepsy with cortical developmental malformations.
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| pubmed:affiliation |
Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine, Detroit, Michigan, USA.
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| pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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