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rdf:type |
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lifeskim:mentions |
umls-concept:C0026809,
umls-concept:C0033578,
umls-concept:C0039194,
umls-concept:C0085358,
umls-concept:C0217846,
umls-concept:C0439831,
umls-concept:C1332717,
umls-concept:C1412371,
umls-concept:C1413244,
umls-concept:C1706438,
umls-concept:C2698600
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pubmed:issue |
35
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pubmed:dateCreated |
2008-9-3
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pubmed:abstractText |
To study T cell responses to tumors in an autochthonous model, we expressed a CD8 T cell epitope SIYRYYGL (SIY) in the prostate of transgenic adenocarcinoma (TRAMP) mice (referred to as TRP-SIY), which spontaneously develop prostate cancer. Naïve SIY-specific CD8 T cells adoptively transferred into TRP-SIY mice became tolerized in the prostate draining lymph nodes. Vaccination of TRP-SIY mice intranasally with influenza virus that expresses the SIY epitope resulted in generation of SIY-specific effector T cells in the lung-draining lymph nodes. These effector T cells expressed TNFalpha and IFNgamma, eliminated SIY peptide-loaded target cells in vivo, and infiltrated prostate tumors, where they rapidly lost the ability to produce effector cytokines. A population of these T cells persisted in prostate tumors but not in lymphoid organs and could be induced to re-express effector functions following cytokine treatment in vitro. These findings suggest that T cells of a given clone can be activated and tolerized simultaneously in different microenvironments of the same host and that effector T cells are rapidly tolerized in the tumors. Our model provides a system to study T cell-tumor interactions in detail and to test the efficacy of cancer immunotherapeutic strategies.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18723683-10051624,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18723683-10371507,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18723683-11108285,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18723683-11244030,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18723683-11429607,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18723683-11564812,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18723683-11832204,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18723683-12094237,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18723683-12479820,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18723683-12663797,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18723683-12681413,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18723683-12951585,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18723683-14630209,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18723683-15023405,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18723683-15153470,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18723683-15247469,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18723683-15340416,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18723683-15368272,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18723683-15623559,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18723683-15766662,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18723683-16034368,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18723683-16136144,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18723683-16382236,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18723683-16423061,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18723683-16515497,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18723683-17129181,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18723683-17237372,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18723683-17306521,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18723683-17659881,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18723683-18056169,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18723683-18097017,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18723683-18753635,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18723683-7724580,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18723683-8044822,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18723683-8573312,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18723683-8608507
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1091-6490
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
2
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pubmed:volume |
105
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
13003-8
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:18723683-Adenocarcinoma,
pubmed-meshheading:18723683-Animals,
pubmed-meshheading:18723683-CD8-Positive T-Lymphocytes,
pubmed-meshheading:18723683-Cross-Priming,
pubmed-meshheading:18723683-Cytokines,
pubmed-meshheading:18723683-Disease Models, Animal,
pubmed-meshheading:18723683-Epitopes, T-Lymphocyte,
pubmed-meshheading:18723683-Immune Tolerance,
pubmed-meshheading:18723683-Lymphocyte Activation,
pubmed-meshheading:18723683-Male,
pubmed-meshheading:18723683-Mice,
pubmed-meshheading:18723683-Orthomyxoviridae,
pubmed-meshheading:18723683-Orthomyxoviridae Infections,
pubmed-meshheading:18723683-Prostate-Specific Antigen,
pubmed-meshheading:18723683-Prostatic Neoplasms,
pubmed-meshheading:18723683-Rats,
pubmed-meshheading:18723683-Vaccination
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pubmed:year |
2008
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pubmed:articleTitle |
Rapid tolerization of virus-activated tumor-specific CD8+ T cells in prostate tumors of TRAMP mice.
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pubmed:affiliation |
Koch Institute for Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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