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pubmed:abstractText |
Despite the current trend towards large epidemiological studies of unrelated individuals, linkage studies in families are still thoroughly being utilized as tools for disease gene mapping. The use of the single-nucleotide-polymorphisms (SNP) array technology in genotyping of family data has the potential to provide more informative linkage data. Nevertheless, SNP array data are not immune to genotyping error which, as has been suggested in the past, could dramatically affect the evidence for linkage especially in selective designs such as affected sib pair (ASP) designs. The influence of genotyping error on selective designs for continuous traits has not been assessed yet.
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pubmed:affiliation |
Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Postzone S-05-P, PO Box 9600 2300 RC Leiden, The Netherlands. j.j.p.lebrec@lumc.nl
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