The N-alkylated derivatives from nitrofurazone were synthesised and evaluated in vitro for their efficacy as antimicrobial agents against representative strains, including methicillin-resistant Staphylococcus aureus (MRSA). The derivative 2a demonstrated greater activity than the prototype and was comparable to currently used antimicrobial drugs.
LabSINFA - Laboratory for the Planning, Synthesis, and Evaluation of Pharmaceutical Products, Department of Pharmaceutical Science, Centre for Health Science, Federal University of Pernambuco, Recife, PE, Brazil.