Linked Life Data

18719914

Source:http://linkedlifedata.com/resource/pubmed/id/18719914

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2009-1-7
pubmed:abstractText
CD8(+) T cells recognizing minor histocompatibility antigens (MiHA) on solid tumor cells may mediate effective graft-versus-tumor (GVT) reactivity after allogeneic stem cell transplantation (SCT). Previously, we identified LRH-1 as a hematopoietic-restricted MiHA encoded by the P2X5 gene. Here, we report that LRH-1 is aberrantly expressed on solid tumor cells. P2X5 mRNA expression is demonstrated in a significant portion of solid tumor cell lines, including renal cell carcinoma (RCC), melanoma, colorectal carcinoma, brain cancer and breast cancer. Importantly, P2X5 gene expression was also detected in a subset of primary solid tumor specimens derived from RCC, brain cancer and breast cancer patients. Furthermore, P2X5 expressing solid tumor cells can be effectively targeted by LRH-1-specific cytotoxic T lymphocytes under inflammatory conditions. The expression of HLA-B7 and CD54 on tumor cells increases upon cytokine stimulation resulting in improved T cell activation as observed by higher levels of degranulation and enhanced tumor cell lysis. Overall, hematopoietic-restricted MiHA LRH-1 is aberrantly expressed on solid tumor cells and may be used as target in GVT-specific immunotherapy after SCT.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1432-0851
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
58
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
429-39
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed-meshheading:18719914-CD8-Positive T-Lymphocytes, pubmed-meshheading:18719914-DNA-Binding Proteins, pubmed-meshheading:18719914-Genotype, pubmed-meshheading:18719914-Hematopoietic System, pubmed-meshheading:18719914-Humans, pubmed-meshheading:18719914-Immunotherapy, pubmed-meshheading:18719914-Intercellular Adhesion Molecule-1, pubmed-meshheading:18719914-Microscopy, Fluorescence, pubmed-meshheading:18719914-Minor Histocompatibility Antigens, pubmed-meshheading:18719914-Neoplasms, pubmed-meshheading:18719914-RNA, Messenger, pubmed-meshheading:18719914-Receptors, Purinergic P2, pubmed-meshheading:18719914-Receptors, Purinergic P2X5, pubmed-meshheading:18719914-Stem Cell Transplantation, pubmed-meshheading:18719914-T-Lymphocytes, pubmed-meshheading:18719914-Transcription Factors, pubmed-meshheading:18719914-Transplantation, Homologous
pubmed:year
2009
pubmed:articleTitle
Aberrant expression of the hematopoietic-restricted minor histocompatibility antigen LRH-1 on solid tumors results in efficient cytotoxic T cell-mediated lysis.
pubmed:affiliation
Central Hematology Laboratory, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't