Linked Life Data

18719710

Source:http://linkedlifedata.com/resource/pubmed/id/18719710

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
2008-8-22
pubmed:abstractText
Proteins that are related to the retinoblastoma tumour suppressor pRB and the E2F transcription factor are conserved in many species of plants and animals. The mammalian orthologues of pRB and E2F are best known for their roles in cell proliferation, but it has become clear that they affect many biological processes. Here we describe the functions of pRB-related proteins and E2F proteins that have emerged from genetic and biochemical experiments in Caenorhabditis elegans and Drosophila melanogaster. The similarities that have been observed between worms, flies and mammals provide insight into the core activities of pRB and E2F proteins and show how a common regulatory module can control various biological functions in different organisms.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1471-0080
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
9
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
713-24
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Conserved functions of the pRB and E2F families.
pubmed:affiliation
Developmental Biology, Utrecht University, Utrecht, The Netherlands. vandenHeuvel@uu.nl
pubmed:publicationType
Journal Article, Review, Research Support, N.I.H., Extramural