Source:http://linkedlifedata.com/resource/pubmed/id/18717644
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
9
|
| pubmed:dateCreated |
2008-9-17
|
| pubmed:abstractText |
Metastasis is a key aspect of tumor malignancy, and several malignant tumors show expression of various mature N-type glycans. In particular, beta1-6 branching N-acetylglucosamine (GlcNAc) is abundantly expressed as a part of high-mannose glycans in various highly metastatic cancers. Phaseolus vulgaris agglutinin-L(4) isolectin (L(4)-PHA), which adheres to beta1-6 GlcNAc specifically, has been used for in situ cancer diagnosis. Bionanocapsules (BNCs), hollow particles with a diameter of approximately 80 nm and composed of hepatitis B surface antigen (HBsAg) and a lipid bilayer, have been developed as human liver-specific nanocapsules for in vivo drug delivery system. In this study, we have generated L(4)-PHA-displaying BNCs (PHA-BNCs) and examined whether L(4)-PHA could retarget the BNCs to malignant tumors as a "biosensor" distinguishing tumor metastaticity. Fluorescence-labeled PHA-BNCs injected systemically into a mouse xenograft model were found to accumulate in beta1-6 GlcNAc-expressing malignant tumors. The PHA-BNCs were able to deliver DNA to the malignant cancer cells. These results open up the possibility of using L(4)-PHA lectin as a targeting molecule in a drug delivery system, and of using PHA-BNCs as a novel nanodevice for malignant tumor-specific bioimaging and drug delivery.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Recombinant,
http://linkedlifedata.com/resource/pubmed/chemical/N-Acetylglucosaminyltransferases,
http://linkedlifedata.com/resource/pubmed/chemical/Nanocapsules,
http://linkedlifedata.com/resource/pubmed/chemical/Phytohemagglutinins,
http://linkedlifedata.com/resource/pubmed/chemical/alpha-1,6-mannosylglycoprotein...
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
1557-7422
|
| pubmed:author | |
| pubmed:issnType |
Electronic
|
| pubmed:volume |
19
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
887-95
|
| pubmed:meshHeading |
pubmed-meshheading:18717644-Animals,
pubmed-meshheading:18717644-Cell Line, Tumor,
pubmed-meshheading:18717644-DNA, Recombinant,
pubmed-meshheading:18717644-Drug Delivery Systems,
pubmed-meshheading:18717644-Gene Therapy,
pubmed-meshheading:18717644-Humans,
pubmed-meshheading:18717644-Liver Neoplasms, Experimental,
pubmed-meshheading:18717644-Male,
pubmed-meshheading:18717644-Mice,
pubmed-meshheading:18717644-Mice, Nude,
pubmed-meshheading:18717644-N-Acetylglucosaminyltransferases,
pubmed-meshheading:18717644-Nanocapsules,
pubmed-meshheading:18717644-Neoplasm Transplantation,
pubmed-meshheading:18717644-Neoplasms,
pubmed-meshheading:18717644-Phaseolus,
pubmed-meshheading:18717644-Phytohemagglutinins,
pubmed-meshheading:18717644-Phytotherapy,
pubmed-meshheading:18717644-Transplantation, Heterologous
|
| pubmed:year |
2008
|
| pubmed:articleTitle |
In vivo delivery of bionanocapsules displaying Phaseolus vulgaris agglutinin-L4 isolectin to malignant tumors overexpressing N-acetylglucosaminyltransferase V.
|
| pubmed:affiliation |
Department of Structural Molecular Biology, Institute of Scientific and Industrial Research, Osaka University, Ibaraki, Osaka 567-0047, Japan.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|