Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
|
pubmed:dateCreated |
1991-9-16
|
pubmed:abstractText |
GABA, applied by iontophoresis to striatal neurons of the rat in an in vivo preparation, depolarized the membrane potential and decreased the input resistance in a dose-dependent manner. The null potential of the GABA depolarization was about -50 mV. In addition, a fading of the GABA-induced response was observed for prolonged and relatively high amino acid application. We conclude that GABA has a depolarizing effect on striatal cells. This is in line with recent in vitro works describing a depolarizing effect of GABA in the rat neostriatum.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
May
|
pubmed:issn |
0887-4476
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
8
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
38-40
|
pubmed:dateRevised |
2003-11-14
|
pubmed:meshHeading |
pubmed-meshheading:1871679-Animals,
pubmed-meshheading:1871679-Corpus Striatum,
pubmed-meshheading:1871679-Dose-Response Relationship, Drug,
pubmed-meshheading:1871679-Iontophoresis,
pubmed-meshheading:1871679-Male,
pubmed-meshheading:1871679-Membrane Potentials,
pubmed-meshheading:1871679-Neurons,
pubmed-meshheading:1871679-Rats,
pubmed-meshheading:1871679-Rats, Inbred Strains,
pubmed-meshheading:1871679-gamma-Aminobutyric Acid
|
pubmed:year |
1991
|
pubmed:articleTitle |
GABA depolarizes neurons in the rat striatum: an in vivo study.
|
pubmed:affiliation |
II Università di Roma, Dipartimento di Sanità Pubblica e Biologia Cellulare, Italy.
|
pubmed:publicationType |
Journal Article
|