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rdf:type |
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|
lifeskim:mentions |
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pubmed:issue |
18
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pubmed:dateCreated |
2008-9-15
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pubmed:abstractText |
Several adamantane-based taxol mimetics were synthesized and found to be cytotoxic at micromolar concentrations and to cause tubulin aggregation. The extent of the aggregation is maximal for N-benzoyl-(2R,3S)-phenylisoseryloxyadamantane (5) and is very sensitive to the structural modifications. A hybrid compound (15), combining adamantane-based taxol mimetic with colchicine was synthesized and found to possess both microtubule depolymerizing and microtubule bundling activities in A549 human lung carcinoma cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1464-3405
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
18
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5091-4
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pubmed:meshHeading |
pubmed-meshheading:18715782-Adamantane,
pubmed-meshheading:18715782-Animals,
pubmed-meshheading:18715782-Antineoplastic Agents, Phytogenic,
pubmed-meshheading:18715782-Brain,
pubmed-meshheading:18715782-Cattle,
pubmed-meshheading:18715782-Colchicine,
pubmed-meshheading:18715782-Combinatorial Chemistry Techniques,
pubmed-meshheading:18715782-Drug Design,
pubmed-meshheading:18715782-Drug Screening Assays, Antitumor,
pubmed-meshheading:18715782-Humans,
pubmed-meshheading:18715782-Microtubules,
pubmed-meshheading:18715782-Molecular Mimicry,
pubmed-meshheading:18715782-Paclitaxel,
pubmed-meshheading:18715782-Structure-Activity Relationship,
pubmed-meshheading:18715782-Tubulin
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pubmed:year |
2008
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pubmed:articleTitle |
Design, synthesis, and bioactivity of putative tubulin ligands with adamantane core.
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pubmed:affiliation |
Department of Chemistry, M. V. Lomonosov Moscow State University, 119992 Moscow, Russian Federation. olgaz@org.chem.msu.ru
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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