Linked Life Data

18715618

Source:http://linkedlifedata.com/resource/pubmed/id/18715618

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
2008-11-17
pubmed:abstractText
Desmoid tumors (desmoid-type fibromatoses) are locally aggressive soft tissue tumors associated with the Wnt/beta-catenin signaling pathway (APC-beta-catenin-Tcf pathway). Matrix metalloproteinase-7, which is one of the target genes of the Wnt/beta-catenin signaling pathway, has been reported to play an important role in tumor progression. We examined the immunohistochemical expression of beta-catenin and matrix metalloproteinase-7 in 72 samples (63 primary and 9 recurrent samples, 63 patients) of sporadic desmoid tumors without familial adenomatous polyposis, and the genetic alteration of the beta-catenin gene in 33 frozen materials (22 primary and 11 recurrent samples, 22 patients). We further examined messenger RNA expression of matrix metalloproteinase 7 by quantitative reverse transcriptase-polymerase chain reaction (RT-PCR) and compared the results with those of normal skeletal muscles. Immunohistochemically, there was a statistically significant correlation between widespread nuclear expression of beta-catenin and overexpression of matrix metalloproteinase-7 (P < .01 in extra-abdominal desmoid, Fisher test). There were 7 missense point mutations in the 22 primary frozen samples (32%). In the beta-catenin mutated group, matrix metalloproteinase-7 messenger RNA expression was significantly higher than that of the beta-catenin wild-type group (P = .0018, Mann-Whitney U test). Our results suggest that the matrix metalloproteinase-7 gene may be up-regulated by mutated or continuously elevated beta-catenin protein and that the matrix metalloproteinase-7 gene may also be targeted in the Wnt/beta-catenin signaling pathway in sporadic desmoid tumors.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1532-8392
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
39
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1802-8
pubmed:meshHeading
pubmed-meshheading:18715618-Adolescent, pubmed-meshheading:18715618-Adult, pubmed-meshheading:18715618-Aged, pubmed-meshheading:18715618-Cell Nucleus, pubmed-meshheading:18715618-Child, pubmed-meshheading:18715618-Child, Preschool, pubmed-meshheading:18715618-Female, pubmed-meshheading:18715618-Fibromatosis, Aggressive, pubmed-meshheading:18715618-Gene Expression Regulation, Neoplastic, pubmed-meshheading:18715618-Humans, pubmed-meshheading:18715618-Infant, pubmed-meshheading:18715618-Male, pubmed-meshheading:18715618-Matrix Metalloproteinase 7, pubmed-meshheading:18715618-Middle Aged, pubmed-meshheading:18715618-Mutation, Missense, pubmed-meshheading:18715618-RNA, Messenger, pubmed-meshheading:18715618-RNA, Neoplasm, pubmed-meshheading:18715618-Reverse Transcriptase Polymerase Chain Reaction, pubmed-meshheading:18715618-Soft Tissue Neoplasms, pubmed-meshheading:18715618-Tumor Markers, Biological, pubmed-meshheading:18715618-Young Adult, pubmed-meshheading:18715618-beta Catenin
pubmed:year
2008
pubmed:articleTitle
Correlation between beta-catenin widespread nuclear expression and matrix metalloproteinase-7 overexpression in sporadic desmoid tumors.
pubmed:affiliation
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812-8582 Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't