|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0004083,
umls-concept:C0007131,
umls-concept:C0019638,
umls-concept:C0025723,
umls-concept:C0025831,
umls-concept:C0026882,
umls-concept:C0079399,
umls-concept:C0079419,
umls-concept:C0086860,
umls-concept:C1519386,
umls-concept:C2745955
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|
pubmed:issue |
11
|
|
pubmed:dateCreated |
2008-10-29
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|
pubmed:abstractText |
O(6)-methylguanine-DNA methyltransferase (MGMT) promoter methylation has been demonstrated to associate with the G:C-->A:T transition mutation in the p53 gene of lung tumors. The purpose of this study is to clarify whether MGMT promoter methylation is not only associated with the shift from the G:C-->A:T mutation in the p53 gene but also whether MGMT increases other mutation patterns in lung tumors.
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|
pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Nov
|
|
pubmed:issn |
1534-4681
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
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pubmed:volume |
15
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
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pubmed:pagination |
3272-7
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pubmed:meshHeading |
pubmed-meshheading:18712569-Adenocarcinoma,
pubmed-meshheading:18712569-Carcinoma, Non-Small-Cell Lung,
pubmed-meshheading:18712569-Carcinoma, Squamous Cell,
pubmed-meshheading:18712569-DNA Methylation,
pubmed-meshheading:18712569-DNA Modification Methylases,
pubmed-meshheading:18712569-DNA Repair Enzymes,
pubmed-meshheading:18712569-Female,
pubmed-meshheading:18712569-Gene Expression Regulation, Enzymologic,
pubmed-meshheading:18712569-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:18712569-Gene Silencing,
pubmed-meshheading:18712569-Humans,
pubmed-meshheading:18712569-Lung Neoplasms,
pubmed-meshheading:18712569-Male,
pubmed-meshheading:18712569-Mutation,
pubmed-meshheading:18712569-Polymerase Chain Reaction,
pubmed-meshheading:18712569-Promoter Regions, Genetic,
pubmed-meshheading:18712569-Sex Factors,
pubmed-meshheading:18712569-Smoking,
pubmed-meshheading:18712569-Tumor Suppressor Protein p53,
pubmed-meshheading:18712569-Tumor Suppressor Proteins
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|
pubmed:year |
2008
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|
pubmed:articleTitle |
Association of O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation with p53 mutation occurrence in non-small cell lung cancer with different histology, gender, and smoking status.
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|
pubmed:affiliation |
Institute of Medical and Molecular Toxicology, Chung Shan Medical University, No. 110, Sec. 1, Chien-Kuo Road, Taichung, Taiwan, ROC.
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pubmed:publicationType |
Journal Article,
Comparative Study
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